Effects of smoking on D2/D3 striatal receptor availability in alcoholics and social drinkers

被引：18
作者：
Albrecht, Daniel S. [1 ,2 ,3 ]
Kareken, David A. [1 ,2 ,3 ,4 ]
Yoder, Karmen K. [1 ,2 ,3 ]
机构：
[1] Indiana Univ Sch Med, Dept Radiol & Imaging Sci, Indianapolis, IN 46202 USA
[2] Indiana Univ Sch Med, Stark Neurosci Res Inst, Indianapolis, IN 46202 USA
[3] Indiana Univ Sch Med, Ctr Neuroimaging, Indianapolis, IN 46202 USA
[4] Indiana Univ Sch Med, Dept Neurol, Indianapolis, IN 46202 USA
来源：
BRAIN IMAGING AND BEHAVIOR | 2013年 / 7卷 / 03期
关键词：
Dopamine; Raclopride; Positron emission tomography; Cigarette smoking; D-2; receptor; POSITRON-EMISSION-TOMOGRAPHY; MESOLIMBIC DOPAMINE TRANSMISSION; NATIONAL EPIDEMIOLOGIC SURVEY; PLATELET MONOAMINE-OXIDASE; NICOTINE DEPENDENCE; VENTRAL STRIATUM; UNITED-STATES; IN-VIVO; RELEASE; BINDING;
D O I：
10.1007/s11682-013-9233-4
中图分类号：
R445 [影像诊断学];
学科分类号：
100207 ;
摘要：
Studies have reported lower striatal D-2/D-3 receptor availability in both alcoholics and cigarette smokers relative to healthy controls. These substances are commonly co-abused, yet the relationship between comorbid alcohol/tobacco abuse and striatal D-2/D-3 receptor availability has not been examined. We sought to determine the degree to which dual abuse of alcohol and tobacco is associated with lower D-2/D-3 receptor availability. Eighty-one subjects (34 nontreatment-seeking alcoholic smokers [NTS-S], 21 social-drinking smokers [SD-S], and 26 social-drinking non-smokers [SD-NS]) received baseline [C-11]raclopride scans. D-2/D-3 binding potential (BPND a parts per thousand B-avail/K-D) was estimated for ten anatomically defined striatal regions of interest (ROIs). Significant group effects were detected in bilateral pre-commissural dorsal putamen, bilateral pre-commissural dorsal caudate; and bilateral post-commissural dorsal putamen. Post-hoc testing revealed that, regardless of drinking status, smokers had lower D-2/D-3 receptor availability than non-smoking controls. Chronic tobacco smokers have lower striatal D-2/D-3 receptor availability than non-smokers, independent of alcohol use. Additional studies are needed to identify the mechanisms by which chronic tobacco smoking is associated with striatal dopamine receptor availability.
引用
收藏
页码：326 / 334
页数：9
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