Enhancement of Thl immune response in mice by the ingestion of Suehirotake (Schizophyllum commune Fries) mycelium

被引：0
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作者：
Kawaguchi, M
Shiomi, R
Tabata, K
Kosuge, Y
Mizumachi, K
Kurisaki, J
机构：
[1] Taito Bio Ind Res Corp, Nagata Ku, Kobe, Hyogo 6530023, Japan
[2] Sumika Tech Informat Serv Inc, Chuo Ku, Osaka 5410043, Japan
[3] Natl Inst Livestock & Grassland Sci, Dept Anim Prod Res, Tsukuba, Ibaraki 3050901, Japan
[4] Natl Inst Agrobiol Sci, Genet Divers Dept, Tsukuba, Ibaraki 3058602, Japan
来源：
JOURNAL OF THE JAPANESE SOCIETY FOR FOOD SCIENCE AND TECHNOLOGY-NIPPON SHOKUHIN KAGAKU KOGAKU KAISHI | 2004年 / 51卷 / 02期
关键词：
D O I：
暂无
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
The culture product of Suehirotake (Schizophyllum commune Fries) mycelium (SCP) is supposed to stimulate cellular immunity. In fact, Schizophyllan (beta-1,6-branched beta-1,3-glucan) contained in SCP has anti-tumor activity. In the present study, we investigated the effects of SCP feeding on cytokine production in mice in order to clarify the immunological effects of SCP as a dietary component. The levels of interleukin (IL)-12 and interferon (IFN)-gamma produced in the culture supernatant of spleen cells from SCP-fed mice were significantly high compared to those in control group (P<0.05). Furthermore, the level of IFN-gamma was dependent on the dose of SCP. The level of tumor necrosis factor (TNF)-alpha was not changed by SCP-feeding. These results suggest that SCP could be useful food with immunomodulating activities by promoting Th 1 immune response via oral route.
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页码：102 / 105
页数：4
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