SYNTHESIS, ANTIBACTERIAL AND ANTIFUNGAL ACTIVITIES OF SOME NOVEL 1-(4,5-DIHYDRO-3,5-DIARYL-1H-PYRAZOL-4-YL)-1H-IMIDAZOLES

被引：0
作者：
Ganguly, Swastika [1 ]
Sureshchandra, Patel Hardik [1 ]
Dev, Abhimanyu [1 ]
机构：
[1] Birla Inst Technol, Dept Pharmaceut Sci, Ranchi 835215, Bihar, India
来源：
INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY | 2013年 / 22卷 / 03期
关键词：
NITROIMIDAZOLE DERIVATIVES; IMIDAZOLE; AGENTS;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel series of eight 1-(4,5-dihydro-3,5-diaryl-1H-pyrazol-4-yl)-1H-imidazoles 3a-h were synthesized by reacting the corresponding 1,3-bis aryl-2-(1H-imidazol-1-yl)-prop-2-en-1-ones 2 with hydrazine hydrate. The compounds have been characterized on the basis of elemental analysis and spectral data. All the compounds were evaluated for their antibacterial and antifungal activities. Among the synthesized compounds, 1-(4,5-dihydro-3-(4-chlorophenyl)-5-(4-bromophenyl)-1H-pyrazol-4-yl)-1H-imidazole 3h exhibited significant inhibitory activity against all the tested bacterial and fungal strains.
引用
收藏
页码：301 / 304
页数：4
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