A highly cytotoxic modified paullone ligand bearing a TEMPO free-radical unit and its copper(II) complex as potential hR2 RNR inhibitors

被引：17

作者：

Dobrov, Anatolie ^{[1
]}

Goeschl, Simone ^{[1
]}

Jakupec, Michael A. ^{[1
]}

Popovic-Bijelic, Ana ^{[2
]}

Graslund, Astrid ^{[3
]}

Rapta, Peter ^{[4
]}

Arion, Vladimir B. ^{[1
]}

机构：

[1] Univ Vienna, Inst Inorgan Chem, A-1090 Vienna, Austria

[2] Univ Belgrade, Fac Phys Chem, Belgrade 11158, Serbia

[3] Stockholm Univ, Dept Biochem & Biophys, S-10691 Stockholm, Sweden

[4] Slovak Univ Technol Bratislava, Dept Phys Chem, SK-81237 Bratislava, Slovakia

来源：

CHEMICAL COMMUNICATIONS | 2013年 / 49卷 / 85期

基金：

奥地利科学基金会;

关键词：

ANTICANCER DRUGS; IN-VITRO; RUTHENIUM; CELLS; THERAPY; DNA;

D O I：

10.1039/c3cc45743e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new paullone-TEMPO conjugate and its copper(II) complex inhibit RNR activity and show high antiproliferative activity in human cancer cell lines.

引用

页码：10007 / 10009

页数：3

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