A highly cytotoxic modified paullone ligand bearing a TEMPO free-radical unit and its copper(II) complex as potential hR2 RNR inhibitors

被引：16
作者：
Dobrov, Anatolie [1 ]
Goeschl, Simone [1 ]
Jakupec, Michael A. [1 ]
Popovic-Bijelic, Ana [2 ]
Graslund, Astrid [3 ]
Rapta, Peter [4 ]
Arion, Vladimir B. [1 ]
机构：
[1] Univ Vienna, Inst Inorgan Chem, A-1090 Vienna, Austria
[2] Univ Belgrade, Fac Phys Chem, Belgrade 11158, Serbia
[3] Stockholm Univ, Dept Biochem & Biophys, S-10691 Stockholm, Sweden
[4] Slovak Univ Technol Bratislava, Dept Phys Chem, SK-81237 Bratislava, Slovakia
来源：
CHEMICAL COMMUNICATIONS | 2013年 / 49卷 / 85期
基金：
奥地利科学基金会;
关键词：
ANTICANCER DRUGS; IN-VITRO; RUTHENIUM; CELLS; THERAPY; DNA;
D O I：
10.1039/c3cc45743e
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A new paullone-TEMPO conjugate and its copper(II) complex inhibit RNR activity and show high antiproliferative activity in human cancer cell lines.
引用
收藏
页码：10007 / 10009
页数：3
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