Co-occurrence of EBV-positive classic Hodgkin lymphoma and B-cell lymphomas of different clonal origins: A case report and literature review

被引：6

作者：

Karube, Kennosuke ^{[1
,2
]}

Takatori, Mitsuyoshi ^{[1
,2
]}

Kohno, Kei ^{[3
]}

Tomoyose, Takeaki ^{[4
,5
]}

Ohshiro, Kazuiku ^{[4
,5
]}

Nakazato, Iwao ^{[5
,6
]}

机构：

[1] Univ Ryukyus, Grad Sch Med, Dept Pathol & Cell Biol, Nishihara, Okinawa, Japan

[2] Univ Ryukyus, Fac Med, Nishihara, Okinawa, Japan

[3] Nagoya Univ Hosp, Dept Pathol & Lab Med, Nagoya, Aichi, Japan

[4] Okinawa Prefectural Nanbu Med Ctr, Dept Hematol, Haebaru, Okinawa, Japan

[5] Childrens Med Ctr, Haebaru, Okinawa, Japan

[6] Okinawa Prefectural Nanbu Med Ctr, Dept Pathol, Haebaru, Okinawa, Japan

来源：

PATHOLOGY INTERNATIONAL | 2020年 / 70卷 / 11期

基金：

日本学术振兴会;

关键词：

classic Hodgkin lymphoma; clonality; composite lymphoma; diffuse large B-cell lymphoma; Epstein-Barr virus; POSTTRANSPLANT LYMPHOPROLIFERATIVE DISORDER; MUCOCUTANEOUS ULCER; DISEASE; PATIENT;

D O I：

10.1111/pin.13012

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Although cases with metachronous or synchronous co-occurrence of classic Hodgkin lymphoma (CHL) and B-cell non-Hodgkin lymphoma (B-NHL) have been reported, few reports have analyzed the clonal relationship between both lesions in detail, especially in Epstein-Barr virus (EBV)-positive settings. Here, we report a case of a 38-year-old male with CHL, followed by the recurrence of EBV-positive mucocutaneous ulcers of the large intestine and EBV-positive diffuse large B-cell lymphoma in the liver. Surprisingly, polymerase chain reaction analysis for immunoglobulin heavy chain gene rearrangement revealed that all lesions were clonally distinct. We further reviewed the literature on synchronous and metachronous co-occurrence of CHL and B-NHL in EBV-positive settings. In contrast to EBV-negative settings, all evaluable cases showed clonally distinct multiple lesions. These findings suggest that histologically and clonally distinct B-cells could simultaneously proliferate in EBV-associated settings, providing a new insight into the pathogenesis of EBV-associated lymphoproliferative disorders.

引用

页码：893 / 898

页数：6

共 19 条

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