Suppression of adult neurogenesis impairs population coding of similar contexts in hippocampal CA3 region

被引：130
作者：
Niibori, Yosuke [1 ]
Yu, Tzong-Shiue [1 ]
Epp, Jonathan R. [1 ]
Akers, Katherine G. [1 ]
Josselyn, Sheena A. [1 ,2 ,3 ]
Frankland, Paul W. [1 ,2 ,3 ]
机构：
[1] Hosp Sick Children, Program Neurosci & Mental Hlth, Toronto, ON M5G 1X8, Canada
[2] Univ Toronto, Dept Physiol, Toronto, ON M5S 1A8, Canada
[3] Univ Toronto, Inst Med Sci, Toronto, ON M5S 1A8, Canada
来源：
NATURE COMMUNICATIONS | 2012年 / 3卷
基金：
加拿大健康研究院;
关键词：
DENTATE GRANULE CELLS; PATTERN SEPARATION; MEMORY; GYRUS; RESPONSES; DISTINCT; NEURONS; BRAIN;
D O I：
10.1038/ncomms2261
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Different places may share common features, but are coded by distinct populations of CA3 neurons in the hippocampus. Here we show that chemical or genetic suppression of adult neurogenesis in the hippocampus impairs this population-based coding of similar (but not dissimilar) contexts. These data provide a neural basis for impaired spatial discrimination following ablation of adult neurogenesis, and support the proposal that adult neurogenesis regulates the efficiency of a pattern separation process in the hippocampus.
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页数：7
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