Geographical distribution of A seropositive myasthenia gravis population

被引:20
作者
Heldal, Anne Taraldsen [1 ]
Eide, Geir Egil [2 ,3 ]
Gilhus, Nils Erik [1 ,4 ]
Romi, Fredrik [4 ]
机构
[1] Univ Bergen, Dept Clin Med, Bergen, Norway
[2] Haukeland Hosp, Clin Res Ctr, N-5021 Bergen, Norway
[3] Univ Bergen, Dept Publ Hlth & Primary Hlth Care, Bergen, Norway
[4] Haukeland Hosp, Dept Neurol, N-5021 Bergen, Norway
关键词
myasthenia gravis; epidemiology; incidence studies; neuromuscular disorder; geographical distribution; ACETYLCHOLINE-RECEPTORS; MULTIPLE-SCLEROSIS; VITAMIN-D; EPIDEMIOLOGY; ANTIBODIES; NORWAY; SAMI;
D O I
10.1002/mus.23271
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Introduction: To assess age- and sex-specific myasthenia gravis (MG) occurrence and incidence in the different geographical regions in Norway and thereby to identify factors that may contribute to the development of MG. Methods: Multiple Poisson regression analysis was used to assess variation in incidence dependent on year, gender and onset age in five geographically defined health regions. Results: The study population comprised 419 individuals with first time seropositive tests from 1995 to 2007. Annual MG incidence ranged from < 1 to 14 per million, with an average of 7.04 per million for all five health regions combined. Conclusions: This is the first nation-wide epidemiological study of seropositive MG that elucidates the geographical differences within a country. The incidence of seropositive MG did not vary significantly between the regions. Mid-Norway tended to have a higher incidence, and North tended to have a lower incidence. Muscle Nerve 45: 815819, 2012
引用
收藏
页码:815 / 819
页数:5
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