A comparison of prostate cancer detection rates by 12 or 6 core biopsy at different prostate-specific antigen densities in Korean men

被引:9
作者
Jeong, Hyeon [2 ]
Jeong, Byong Chang [2 ]
Kwak, Cheol [1 ]
Lee, Eunsik [1 ]
Lee, Sang Eun [3 ]
Kim, Tae Beom [1 ]
机构
[1] Seoul Natl Univ Hosp, Dept Urol, Seoul 110744, South Korea
[2] Seoul Municipal Boramae Hosp, Dept Urol, Seoul, South Korea
[3] Seoul Natl Univ, Bundang Hosp, Dept Urol, Seoul, South Korea
关键词
prostate cancer; prostate-specific antigen; biopsy;
D O I
10.1007/s00345-008-0264-1
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Objectives To evaluate the diagnostic value of 12 core biopsy versus sextant biopsy at different prostatic-specific antigen densities (PSAD). Methods We retrospectively analyzed the records of 1,463 patients who underwent transrectal ultrasound-guided prostate biopsies at our institution. 995 patients underwent 12 core biopsy and 468 sextant biopsy of the prostate. The cancer detection rates achieved by these two methods were analyzed at different PSAD levels. Results All patients were stratified into 5 groups according to PSAD level; group A: PSAD < 0.1 (n = 290), group B: 0.1 <= PSAD < 0.2 (n = 572), group C: 0.2 <= PSAD < 0.3 (n = 248), group D: 0.3 <= PSAD < 0.4 (n = 122), and group E: PSAD >= 0.4 (n = 231). In group B, 12 core biopsy had a higher detection rate than 6 core biopsy (P = 0.017). Conclusions These results demonstrate 12 core biopsy is better able to detect cancer than 6 core biopsy in patients with a PSAD in the range 0.1-0.2, which suggests that PSAD be considered when deciding on the number of prostate biopsy cores required.
引用
收藏
页码:395 / 400
页数:6
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