Organometallic Ruthenium and Osmium Compounds of Pyridin-2-and-4-ones as Potential Anticancer Agents

被引：15

作者：

Henke, Helena ^{[1
,2
]}

Kandioller, Wolfgang ^{[1
]}

Hanif, Muhammad ^{[3
]}

Keppler, Bernhard K. ^{[1
,2
]}

Hartinger, Christian G. ^{[1
,2
,4
]}

机构：

[1] Univ Vienna, Inst Inorgan Chem, AT-1090 Vienna, Austria

[2] Univ Vienna, AT-1090 Vienna, Austria

[3] COMSATS Inst Informat Technol, Dept Chem, Abbottabad 22060, Pakistan

[4] Univ Auckland, Sch Chem Sci, Auckland 1010, New Zealand

来源：

CHEMISTRY & BIODIVERSITY | 2012年 / 9卷 / 09期

基金：

奥地利科学基金会;

关键词：

Bioorganometallics; Anticancer activity; Ruthenium complexes; Pyridinones; Osmium complexes; MRI CONTRAST AGENTS; IN-VITRO; IRON(III)-CHELATING PROPERTIES; METAL-COMPOUNDS; COMPLEXES; LIGANDS; INHIBITORS; CHEMISTRY; MALTOL; DRUGS;

D O I：

10.1002/cbdv.201200005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Organometallic RuII compounds are among the most widely studied anticancer agents. Functionalizing metal centers with biomolecule-derived ligands has been shown to be a promising strategy to improve the antiproliferative activity of metal-based chemotherapeutics. Herein, the synthesis of a series of novel 3-hydroxypyridin-2-one-derived ligands and their MII(?6-p-cymene) half-sandwich complexes (M=Ru, Os) is described. The compounds were characterized by 1D- and 2D-NMR spectroscopy, and elemental analysis.

引用

页码：1718 / 1727

页数：10

共 48 条

[1] Thioamide Hydroxypyrothiones Supersede Amide Hydroxypyrothiones in Potency against Anthrax Lethal Factor [J].

Agrawal, Arpita ;

de Oliveira, Cesar Augusto F. ;

Cheng, Yuhui ;

Jacobsen, Jennifer A. ;

McCammon, J. Andrew ;

Cohen, Seth M. .

JOURNAL OF MEDICINAL CHEMISTRY, 2009, 52 (04) :1063-1074

[2] Organometallic ruthenium-based antitumor compounds with novel modes of action [J].

Ang, Wee Han ;

Casini, Angela ;

Sava, Gianni ;

Dyson, Paul J. .

JOURNAL OF ORGANOMETALLIC CHEMISTRY, 2011, 696 (05) :989-998

[3] ARENE RUTHENIUM(II) COMPLEXES FORMED BY DEHYDROGENATION OF CYCLOHEXADIENES WITH RUTHENIUM(III) TRICHLORIDE [J].

BENNETT, MA ;

SMITH, AK .

JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS, 1974, (02) :233-241

[4] (ETA-6-HEXAMETHYLBENZENE)RUTHENIUM COMPLEXES [J].

BENNETT, MA ;

HUANG, TN ;

MATHESON, TW ;

SMITH, AK .

INORGANIC SYNTHESES, 1982, 21 :74-78

[5]

Bernstein Lawrence R., 2000, Metal-Based Drugs, V7, P33, DOI 10.1155/MBD.2000.33

[6]

DALE LD, 1989, ANTI-CANCER DRUG DES, V4, P295

[7] Gd-Hydroxypyridinone (HOPO)-Based High-Relaxivity Magnetic Resonance Imaging (MRI) Contrast Agents [J].

Datta, Ankona ;

Raymond, Kenneth N. .

ACCOUNTS OF CHEMICAL RESEARCH, 2009, 42 (07) :938-947

[8] SYNTHESIS, PHYSICOCHEMICAL PROPERTIES, AND BIOLOGICAL EVALUATION OF N-SUBSTITUTED 2-ALKYL-3-HYDROXY-4(1H)-PYRIDINONES - ORALLY-ACTIVE IRON CHELATORS WITH CLINICAL POTENTIAL [J].

DOBBIN, PS ;

HIDER, RC ;

HALL, AD ;

TAYLOR, PD ;

SARPONG, P ;

PORTER, JB ;

XIAO, GY ;

VANDERHELM, D .

JOURNAL OF MEDICINAL CHEMISTRY, 1993, 36 (17) :2448-2458

[9] Metal-based antitumour drugs in the post genomic era [J].

Dyson, PJ ;

Sava, G .

DALTON TRANSACTIONS, 2006, (16) :1929-1933

[10] Interactions of insulin-mimetic zinc(II) complexes with cell constituents:: Glutathione and ATP [J].

Enyedy, Eva Anna ;

Lakatos, Andrea ;

Horvath, Laszlo ;

Kiss, Tamas .

JOURNAL OF INORGANIC BIOCHEMISTRY, 2008, 102 (07) :1473-1485

← 1 2 3 4 5 →