Proinflammatory effects of Staphylococcus aureus exotoxin B on nasal epithelial cells

被引：30

作者：

Damm, M ^{[1
]}

Quante, G ^{[1
]}

Rosenbohm, J ^{[1
]}

Rieckmann, R ^{[1
]}

机构：

[1] Univ Cologne, Dept Otorhinolaryngol Head & Neck Surg, D-50924 Cologne, Germany

来源：

OTOLARYNGOLOGY-HEAD AND NECK SURGERY | 2006年 / 134卷 / 02期

关键词：

D O I：

10.1016/j.otohns.2005.11.016

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

OBJECTIVE: The aim of this study was to evaluate the effects of Staphlylococcus aureus exotoxin B (SE-B) on proinflammatory cytokine/chemokine releases in primary nasal epithelial cell cultures (NECC) of subjects with and without chronic rhinosinusitis (CRS). STUDY DESIGN AND SETTING: NECC (CRS: n = 14; Controls: n = 11) were stimulated with SE-B. Protein concentrations of interleukin-(IL-1 beta, IL-6, and IL-8 levels were measured in NECC supernatants by ELISA before (TO) and after 24 hr stimulation with SE-B (TI). RESULTS: TO: supernatants of the NECC of CRS patients contained significant lower levels of IL-8 (2.1 ng/ml) compared to Controls (IL-8: 6.2 ng/ml; P < 0.01). TI: SE-B induced a significant increase of IL-6 in NECC (P < 0.001). IL-1 beta was not detectable. CONCLUSIONS: This is the first study evaluating the effects of exotoxins on NECC. SE-B showed proinflammatory effects on NECC. SIGNIFICANCE: Our data Suggest that resident NECC are involved in immunological responses to Staphylococcus aureus toxins, supplementing the so-called "superantigen hypothesis" in CRS. (c) 2006 American Academy of Otolaryngology-Head and Neck Surgery Foundation, Inc. All rights reserved.

引用

页码：245 / 249

页数：5

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