Chemo-enzymatic synthesis of rafffinose-branched polyelectrolytes and self-assembly application in microcapsules

被引：8
作者：
Wu, Q [1 ]
Chen, ZC [1 ]
Lu, DS [1 ]
Lin, XF [1 ]
机构：
[1] Zhejiang Univ, Dept Chem, Hangzhou 310027, Peoples R China
来源：
MACROMOLECULAR BIOSCIENCE | 2006年 / 6卷 / 01期
关键词：
biopolymer; chemo-enzymatic synthesis; radical polymerization; raffinose; self-assembly;
D O I：
10.1002/mabi.200500191
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A novel biocompatible polyelectrolyte poly(vinyl raffinose-co-acrylic acid) (PRCA) containing a raffnose branch was prepared via redox polymerization using Fe2(+)/K2S2O8/H2O2 starting from enzymatically-synthesized monomer: 1-O-vinyldecanedioyl raffinose. Copolymers with different monomer feed ratios were prepared and characterized with IR, NMR, and GPC. PRCA can be alternated with polycation to form microcapsules on a crystals template by electrostatic layer-by-layer technique. The multilayers of PRCA/poly(methacryloyloxyethyldimethylbenzyl ammonium chloride) (PMBA) on quartz slides and PRCA/poly-(dimethyidiallyl ammonium chloride) (PDDA) on acyclovir crystals template were fabricated and characterized with UV-Vis spectra, the microelectrophoretic measurement, and TEM. Hollow capsules can be formed after the removal of acyclovir crystals template in a buffer solution. The nanocapsule-carrying galactose residue is a potential targeting drug-controlled delivery systems.
引用
收藏
页码：78 / 83
页数：6
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