Recent developments in the chemistry of quinazolinone alkaloids

被引：333

作者：

Kshirsagar, U. A. ^{[1
]}

机构：

[1] Savitribai Phule Pune Univ, Univ Pune, Dept Chem, Pune 411007, Maharashtra, India

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2015年 / 13卷 / 36期

关键词：

ENANTIOSELECTIVE TOTAL SYNTHESES; CONCISE TOTAL-SYNTHESIS; POT TOTAL SYNTHESES; BENZODIAZEPINE ALKALOIDS; ENDOPHYTIC FUNGUS; CATALYZED SYNTHESIS; LUOTONIN-A; QUINOLINE; TRYPTANTHRIN; METABOLITES;

D O I：

10.1039/c5ob01379h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Quinazolinones, an important class of fused heterocyclic alkaloids has attracted high attention in organic and medicinal chemistry due to their significant and wide range of biological activities. There are approximately 150 naturally occurring quinazolinone alkaloids known till 2005. Several new quinazolinone alkaloids (similar to 55) have been isolated in the last decade. Natural quinazolinones with exotic structural features and remarkable biological activities have incited a lot of activities in the synthetic community towards the development of new synthetic strategies and approaches for the total synthesis of quinazolinone alkaloids. This review is focused on these advances in the chemistry of quinazolinone alkaloids in the last decade. This article covers the newly isolated quinazolinone natural products with their biological activities and the recently reported total syntheses of quinazolinone alkaloids from 2006 to 2015.

引用

页码：9336 / 9352

页数：17

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