Carbon Monoxide and Its Controlled Release: Therapeutic Application, Detection, and Development of Carbon Monoxide Releasing Molecules (CORMs)

被引：250

作者：

Ling, Ken ^{[1
,2
]}

Men, Fang ^{[3
]}

Wang, Wei-Ci ^{[4
]}

Zhou, Ya-Qun ^{[5
]}

Zhang, Hao-Wen ^{[1
]}

Ye, Da-Wei ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Canc Ctr, Wuhan 430030, Hubei, Peoples R China

[2] Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Dept Anesthesiol, Wuhan 430030, Hubei, Peoples R China

[3] Wuhan Univ, Coll Chem & Mol Sci, Wuhan 430072, Hubei, Peoples R China

[4] Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Dept Vasc Surg, Wuhan 430030, Hubei, Peoples R China

[5] Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Anesthesiol Inst, Wuhan 430030, Hubei, Peoples R China

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2018年 / 61卷 / 07期

关键词：

ISCHEMIA-REPERFUSION INJURY; TRACKABLE CO DELIVERY; EX-VIVO APPLICATION; HEME OXYGENASE-1; FLUORESCENT-PROBE; DRUG-DELIVERY; VISIBLE-LIGHT; NITRIC-OXIDE; ISCHEMIA/REPERFUSION INJURY; IN-VIVO;

D O I：

10.1021/acs.jmedchem.6b01153

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Carbon monoxide (CO) is attracting increasing attention because of its role as a gasotransmitter with cytoprotective and homeostatic properties. Carbon monoxide releasing molecules (CORMs) are spatially and temporally controlled CO releasers that exhibit superior and more effective pharmaceutical traits than gaseous CO because of their chemistry and structure. Experimental and preclinical research in animal models has shown the therapeutic potential of inhaled CO and CORMs, and the biological effects of CO and CORMs have also been observed in preclinical trials via the genetic modulation of heme oxygenase-1 (HO-1). In this review, we describe the pharmaceutical use of CO and CORMS, methods of detecting CO release, and developments in CORM design and synthesis. Many valuable clinical CORMs formulated using macromolecules and nanomaterials are also described.

引用

页码：2611 / 2635

页数：25

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