Suzuki coupling of oxazoles

被引：77
作者：
Flegeau, Emmanuel Ferrer
Popkin, Matthew E.
Greaney, Michael F.
机构：
[1] Univ Edinburgh, Dept Chem, Edinburgh EH9 3JJ, Midlothian, Scotland
[2] GlaxoSmithKline, Chem Dev, Tonbridge TN11 9AN, Kent, England
来源：
ORGANIC LETTERS | 2006年 / 8卷 / 12期
关键词：
D O I：
10.1021/ol060591j
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A protocol for the functionalization of the oxazole 2- and 4-positions using the Suzuki coupling reaction is described. 2-Aryl-4-trifloyloxazoles undergo rapid, microwave-assisted coupling with a range of aryl and heteroaryl boronic acids in good to excellent yields. The methodology is similarly effective using 4-aryl-2-chlorooxazoles as the coupling partner and has been extended to the synthesis of a novel class of homo-and heterodimeric 4,4-linked dioxazoles.
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收藏
页码：2495 / 2498
页数：4
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