Diabetic Complications in Obese Type 2 Diabetic Rat Models

被引：75

作者：

Katsuda, Yoshiaki ^{[1
]}

Ohta, Takeshi ^{[1
]}

Miyajima, Katsuhiro ^{[1
]}

Kemmochi, Yusuke ^{[1
]}

Sasase, Tomohiko ^{[1
]}

Tong, Bin ^{[2
]}

Shinohara, Masami ^{[3
]}

Yamada, Takahisa ^{[2
]}

机构：

[1] Japan Tobacco Inc, Cent Pharmaceut Res Inst, Takatsuki, Osaka 5691125, Japan

[2] Niigata Univ, Grad Sch Sci & Technol, Lab Anim Genet, Nishi Ku, Niigata 9502181, Japan

[3] CLEA Japan Inc, Planning & Dev Sect, Meguro Ku, Tokyo 1538533, Japan

来源：

EXPERIMENTAL ANIMALS | 2014年 / 63卷 / 02期

关键词：

animal model; diabetes; diabetic complication; obese; SDT fatty rat; BONE-MINERAL DENSITY; TOKUSHIMA FATTY RATS; ALDOSE REDUCTASE INHIBITOR; IMPAIRED GLUCOSE-TOLERANCE; GLYCATION END-PRODUCTS; HYPOGONADOTROPIC HYPOGONADISM; MICROVASCULAR RETINOPATHY; POSSIBLE PARTICIPATION; PERIPHERAL NEUROPATHY; INSULIN-RESISTANCE;

D O I：

10.1538/expanim.63.121

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

We overviewed the pathophysiological features of diabetes and its complications in obese type 2 diabetic rat models: Otsuka Long-Evans Tokushima fatty (OLETF) rat, Wistar fatty rat, Zucker diabetic fatty (ZDF) rat and Spontaneously diabetic Toni (SDT) fatty rat. Pancreatic changes with progression of diabetes were classified into early changes, such as islet hypertrophy and degranulation of 13 cells, and degenerative changes, such as islet atrophy and fibrosis of islet with infiltration of inflammatory cells. Renal lesions in tubuli and glomeruli were observed, and nodular lesions in glomeruli were notable changes in OLETF and SDT fatty rats. Among retinal changes, folding and thickening were interesting findings in SDT fatty rats. A decrease of motor nerve conduction velocity with progression of diabetes was presented in obese diabetic rats. Other diabetic complications, osteoporosis and sexual dysfunction, were also observed. Observation of bone metabolic abnormalities, including decrease of osteogenesis and bone mineral density, and sexual dysfunction, including hypotestosteronemia and erectile dysfunction, in obese type 2 diabetic rats have been reported.

引用

页码：121 / 132

页数：12

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