Shift work and incidence of dementia: A Danish Nurse Cohort study

被引:35
作者
Jorgensen, Jeanette Therming [1 ]
Hansen, Johnni [2 ]
Westendorp, Rudi G. J. [3 ,4 ]
Nabe-Nielsen, Kirsten [5 ]
Stayner, Leslie Thomas [6 ]
Simonsen, Mette Kildevaeld [7 ]
Andersen, Zorana Jovanovic [1 ,8 ]
机构
[1] Univ Copenhagen, Dept Publ Hlth, Sect Environm Hlth, Copenhagen, Denmark
[2] Danish Canc Soc, Danish Canc Res Ctr, Copenhagen, Denmark
[3] Univ Copenhagen, Dept Publ Hlth, Sect Epidemiol, Copenhagen, Denmark
[4] Univ Copenhagen, Ctr Hlth Aging, Copenhagen, Denmark
[5] Univ Copenhagen, Dept Publ Hlth, Sect Social Med, Copenhagen, Denmark
[6] Univ Illinois, Sch Publ Hlth, Div Epidemiol & Biostat, Chicago, IL USA
[7] Frederiksberg Univ Hosp, Diakonissestiftelsen & Parker Inst, Frederiksberg, Denmark
[8] Nykobing F Hosp, Ctr Epidemiol Res, Hosp Vej, Nykobing, Denmark
关键词
Alzheimer's disease and dementia; cohort study; Danish Nurse Cohort; Denmark; neurodegenerative disease; night shift work; shift work; working time; REPORTED SLEEP DISTURBANCE; RISK; ASSOCIATION; DISEASE; COGNITION; VALIDITY; EXPOSURE;
D O I
10.1002/alz.12126
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Introduction: A few studies suggest that working night and rotating shifts increase the risk of dementia. We examined the association between shift work and the incidence of dementia in a cohort of female Danish nurses. Methods: We linked Danish Nurse Cohort participants, who reported work schedules (day, evening, night, rotating shifts) in 1993 and/or 1999 and their duration in 2009, to Danish registers to obtain information on dementia hospitalizations and prescription medication until November 2018. Results: Among 6048 nurses who reported work schedules in 1993 and 1999, nurses working night shifts >= 6 years had higher dementia incidence (hazard ratio: 2.43, 95% confidence interval: 1.39 to 4.23) than those working day shifts >= 6 years. Among 8059 nurses who reported shift work duration, nurses working night shifts >= 6 years had higher dementia incidence than those working night shifts <1 year (1.47, 1.06 to 2.06). Discussion: Persistent night shift work may increase the risk of dementia.
引用
收藏
页码:1268 / 1279
页数:12
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