Intrathecal oligoclonal IgG synthesis in multiple sclerosis

被引：123

作者：

Petzold, Axel ^{[1
,2
]}

机构：

[1] Vrije Univ Amsterdam Med Ctr, Dept Neurol, Amsterdam, Netherlands

[2] UCL Inst Neurol, Neuroimmunol & CSF Lab, London, England

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2013年 / 262卷 / 1-2期

关键词：

Diagnostic criteria; Cerebrospinal fluid; Multiple sclerosis; CEREBROSPINAL-FLUID ANALYSIS; ACUTE OPTIC NEURITIS; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; AGAROSE-GEL ELECTROPHORESIS; REVISED MCDONALD CRITERIA; B-CELLS; LIGHT-CHAINS; DIFFERENTIAL-DIAGNOSIS; PERSISTING IMPORTANCE; BASIC-PROTEIN;

D O I：

10.1016/j.jneuroim.2013.06.014

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The diagnosis of multiple sclerosis is based on dissemination in time and space. Before 2010 lack of evidence for dissemination in space could be substituted by a paraclinical test, cerebrospinal fluid (CSF) oligoclonal bands (OCBs). The present meta-analysis (13,467 patients) shows that the diagnostic specificity of OCB drops from 94% to 61% if inflammatory etiologies are considered. Importantly, this was not caused by poor laboratory practice. This review on CSF OCB further illustrates the conceptional problem of substituting dissemination in space with a biomarker. The potential prognostic value of intrathecal OCB will need to be tested prospectively. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：1 / 10

页数：10

共 110 条

[1] Utility of oligoclonal IgG band detection for MS diagnosis in daily clinical practice [J].

Abraira, V. ;

Alvarez-Cermeno, J. C. ;

Arroyo, R. ;

Camara, C. ;

Casanova, B. ;

Cubillo, S. ;

de Andres, C. ;

Espejo, C. ;

Fernandez, O. ;

Ferrer, J. ;

Figueredo, M. A. ;

Garcia-Merino, A. ;

Garcia-Sanchez, M. I. ;

Garcia-Trujillo, J. A. ;

Gomez, M. ;

Gonzalez-Oria, C. ;

Gosis, A. ;

Izquierdo, G. ;

Jimenez, J. ;

Lopez-Trascasa, M. ;

Montalban, X. ;

Moreno, M. J. ;

Munoz, D. ;

Nunez, V. ;

Muriel, A. ;

Navarro, J. ;

Olascoaga, J. ;

Oreja-Guevara, C. ;

Prada, A. ;

Ramil, E. ;

Ramo-Tello, C. ;

Rodriguez, C. ;

Rodriguez, E. ;

Rodriguez-Frias, F. ;

Rodriguez-Antigueedad, A. ;

Rodriguez-Molina, J. J. ;

Ruiz, E. ;

Saiz, A. ;

Sarasola, E. ;

Simo, M. ;

Yaguee, J. ;

Villar, L. M. .

JOURNAL OF IMMUNOLOGICAL METHODS, 2011, 371 (1-2) :170-173

[2] CEREBROSPINAL-FLUID IN THE DIAGNOSIS OF MULTIPLE-SCLEROSIS - A CONSENSUS REPORT [J].

ANDERSSON, M ;

ALVAREZCERMENO, J ;

BERNARDI, G ;

COGATO, I ;

FREDMAN, P ;

FREDERIKSEN, J ;

FREDRIKSON, S ;

GALLO, P ;

GRIMALDI, LM ;

GRONNING, M ;

KEIR, G ;

LAMERS, K ;

LINK, H ;

MAGALHAES, A ;

MASSARO, AR ;

OHMAN, S ;

REIBER, H ;

RONNBACK, L ;

SCHLUEP, M ;

SCHULLER, E ;

SINDIC, CJM ;

THOMPSON, EJ ;

TROJANO, M ;

WURSTER, U .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1994, 57 (08) :897-902

[3] High sensitivity of free lambda and free kappa light chains for detection of intrathecal immunoglobulin synthesis in cerebrospinal fluid [J].

Arneth, B. ;

Birklein, F. .

ACTA NEUROLOGICA SCANDINAVICA, 2009, 119 (01) :39-44

[4]

Axelsson M, 2011, MULT SCLER J, V17, pS281

[5] Relevance of immunological variables in neuroborreliosis and multiple sclerosis [J].

Bednárová, J ;

Stourac, P ;

Adam, P .

ACTA NEUROLOGICA SCANDINAVICA, 2005, 112 (02) :97-102

[6] The clinical significance of a single abnormal immunoglobulin band in cerebrospinal fluid electrophoresis [J].

BenHur, T ;

Abramsky, O ;

River, Y .

JOURNAL OF THE NEUROLOGICAL SCIENCES, 1996, 136 (1-2) :159-161

[7] Towards complete and,accurate reporting of studies of diagnostic accuracy: the STARD initiative [J].

Bossuyt, PM ;

Reitsma, JB ;

Bruns, DE ;

Gatsonis, CA ;

Glasziou, PP ;

Irwig, LM ;

Lijmer, JG ;

Moher, D ;

Rennie, D ;

de Vet, HCE .

BRITISH MEDICAL JOURNAL, 2003, 326 (7379) :41-44

[8] CSF isoelectrofocusing in a large cohort of MS and other neurological diseases [J].

Bourahoui, A ;

de Seze, J ;

Guttierez, R ;

Onraed, B ;

Hennache, B ;

Ferriby, D ;

Stojkovic, T ;

Vermersch, P .

EUROPEAN JOURNAL OF NEUROLOGY, 2004, 11 (08) :525-529

[9] Lipid arrays identify myelin-derived lipids and lipid complexes as prominent targets for oligoclonal band antibodies in multiple sclerosis [J].

Brennan, Kathryn M. ;

Galban-Horcajo, Francesc ;

Rinaldi, Simon ;

O'Leary, Colin P. ;

Goodyear, Carl S. ;

Kalna, Gabriela ;

Arthur, Ariel ;

Elliot, Christina ;

Barnett, Sue ;

Linington, Christopher ;

Bennett, Jeffrey L. ;

Owens, Gregory P. ;

Willison, Hugh J. .

JOURNAL OF NEUROIMMUNOLOGY, 2011, 238 (1-2) :87-95

[10] The Chemokine CXCL13 Is a Prognostic Marker in Clinically Isolated Syndrome (CIS) [J].

Brettschneider, Johannes ;

Czerwoniak, Anne ;

Senel, Makbule ;

Fang, Lubin ;

Kassubek, Jan ;

Pinkhardt, Elmar ;

Lauda, Florian ;

Kapfer, Tamara ;

Jesse, Sarah ;

Lehmensiek, Vera ;

Ludolph, Albert C. ;

Otto, Markus ;

Tumani, Hayrettin .

PLOS ONE, 2010, 5 (08)

← 1 2 3 4 5 6 7 8 9 10 →