DNA Vaccine Delivery and Improved Immunogenicity

被引：67

作者：

Porter, Kevin R. ^{[1
]}

Raviprakash, Kanakatte ^{[1
]}

机构：

[1] Naval Med Res Ctr, Infect Dis Directorate, Silver Spring, MD 20910 USA

来源：

CURRENT ISSUES IN MOLECULAR BIOLOGY | 2017年 / 22卷

关键词：

IMMUNE-RESPONSES; TRANSCUTANEOUS IMMUNIZATION; CUTANEOUS DELIVERY; ANTIBODY-RESPONSES; BACTERIAL GHOSTS; DENDRITIC CELLS; PHASE-I; INFLUENZA; VIRUS; SALMONELLA;

D O I：

10.21775/cimb.022.129

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The promise of DNA vaccines is as compelling today as it was more than a decade ago. Ease of manufacture, stability at ambient temperatures without the need for a cold chain and its ability to mimic natural infections and elicit appropriate immune responses makes this vaccine platform extremely attractive. Although, human clinical trials of DNA vaccines have yielded less than optimal results, the approval and licensing of a few veterinary vaccines is testimony to the proof of-concept and the hope that licensed DNA vaccines for human use may not be too far away. Delivery and targeting of immunologically relevant cells appears to be the major hurdle in maximizing the immunogenicity of DNA vaccines. Several different approaches that are currently pursued in achieving this objective are discussed.

引用

页码：129 / 138

页数：10

共 60 条

[1]

[Anonymous], SMALL, V6, P1776

[2]

Atmar RL, 2010, EXPERT REV VACCINES, V9, P1399, DOI [10.1586/erv.10.134, 10.1586/ERV.10.134]

[3] Immunogenicity and clinical protection against equine influenza by DNA vaccination of ponies [J].

Ault, Alida ;

Zajac, Alyse M. ;

Kong, Wing-Pui ;

Gorres, J. Patrick ;

Royals, Michael ;

Wei, Chih-Jen ;

Bao, Saran ;

Yang, Zhi-yong ;

Reedy, Stephanie E. ;

Sturgill, Tracy L. ;

Page, Allen E. ;

Donofrio-Newman, Jennifer ;

Adams, Amanda A. ;

Balasuriya, Udeni B. R. ;

Horohov, David W. ;

Chambers, Thomas M. ;

Nabel, Gary J. ;

Rao, Srinivas S. .

VACCINE, 2012, 30 (26) :3965-3974

[4] Langerin negative dendritic cells promote potent CD8+ T-cell priming by skin delivery of live adenovirus vaccine microneedle arrays [J].

Bachy, Veronique ;

Hervouet, Catherine ;

Becker, Pablo D. ;

Chorro, Laurent ;

Carlin, Leo M. ;

Herath, Shanthi ;

Papagatsias, Timos ;

Barbaroux, Jean-Baptiste ;

Oh, Sea-Jin ;

Benlahrech, Adel ;

Athanasopoulos, Takis ;

Dickson, George ;

Patterson, Steven ;

Kwon, Sung-Yun ;

Geissmann, Frederic ;

Klavinskis, Linda S. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (08) :3041-3046

[5] Broad and potent immune responses to a low dose intradermal HIV-1 DNA boosted with HIV-1 recombinant MVA among healthy adults in Tanzania [J].

Bakari, Muhammad ;

Aboud, Said ;

Nilsson, Charlotta ;

Francis, Joel ;

Buma, Deus ;

Moshiro, Candida ;

Aris, Eric A. ;

Lyamuya, Eligius F. ;

Janabi, Mohamed ;

Godoy-Ramirez, Karina ;

Joachim, Agricola ;

Polonis, Victoria R. ;

Brave, Andreas ;

Earl, Patricia ;

Robb, Merlin ;

Marovich, Mary ;

Wahren, Britta ;

Pallangyo, Kisali ;

Biberfeld, Gunnel ;

Mhalu, Fred ;

Sandstrom, Eric .

VACCINE, 2011, 29 (46) :8417-8428

[6] Microneedle-Based Transcutaneous Immunisation in Mice with N-Trimethyl Chitosan Adjuvanted Diphtheria Toxoid Formulations [J].

Bal, Suzanne M. ;

Ding, Zhi ;

Kersten, Gideon F. A. ;

Jiskoot, Wim ;

Bouwstra, Joke A. .

PHARMACEUTICAL RESEARCH, 2010, 27 (09) :1837-1847

[7] A polyvalent influenza DNA vaccine applied by needle-free intradermal delivery induces cross-reactive humoral and cellular immune responses in pigs [J].

Borggren, Marie ;

Nielsen, Jens ;

Karlsson, Ingrid ;

Dalgaard, Tina S. ;

Trebbien, Ramona ;

Williams, James A. ;

Fomsgaard, Anders .

VACCINE, 2016, 34 (32) :3634-3640

[8] A Phase 1 clinical trial of Hantaan virus and Puumala virus M-segment DNA vaccines for hemorrhagic fever with renal syndrome [J].

Boudreau, Ellen F. ;

Josleyn, Matthew ;

Ullman, Diane ;

Fisher, Diana ;

Dalrymple, Lonnie ;

Sellers-Myers, Karen ;

Loudon, Peter ;

Rusnak, Janice ;

Rivard, Robert ;

Schmaljohn, Connie ;

Hooper, Jay W. .

VACCINE, 2012, 30 (11) :1951-1958

[9] Phase I Study of a Herpes Simplex Virus Type 2 (HSV-2) DNA Vaccine Administered to Healthy, HSV-2-Seronegative Adults by a Needle-Free Injection System [J].

Cattamanchi, Ashok ;

Posavad, Christine M. ;

Wald, Anna ;

Baine, Yaela ;

Moses, Jennifer ;

Higgins, Terry J. ;

Ginsberg, Richard ;

Ciccarelli, Richard ;

Corey, Lawrence ;

Koelle, David M. .

CLINICAL AND VACCINE IMMUNOLOGY, 2008, 15 (11) :1638-1643

[10] Improved DNA vaccination by skin-targeted delivery using dry-coated densely-packed microprojection arrays [J].

Chen, Xianfeng ;

Kask, Angela Shaulov ;

Crichton, Michael L. ;

McNeilly, Celia ;

Yukiko, Sally ;

Dong, Lichun ;

Marshak, Joshua O. ;

Jarrahian, Courtney ;

Fernando, Germain J. P. ;

Chen, Dexiang ;

Koelle, David M. ;

Kendall, Mark A. F. .

JOURNAL OF CONTROLLED RELEASE, 2010, 148 (03) :327-333

← 1 2 3 4 5 6 →