L1CAM Immunopositivity in Anaplastic Supratentorial Ependymomas: Correlation With Clinical and Histological Parameters

被引:13
作者
Chavali, Pooja [1 ]
Rao, Shilpa [1 ]
Palavalasa, Sravya [1 ]
Bevinahalli, Nandeesh [1 ]
Muthane, Yasha T. C. [1 ]
Sadashiva, Nishanth [1 ]
Santosh, Vani [1 ]
机构
[1] Natl Inst Mental Hlth & Neurosci, Bangalore, Karnataka, India
关键词
supratentorial anaplastic ependymoma; histomorphological spectrum; RELA fusion; L1CAM; p65; CLEAR-CELL EPENDYMOMA; PATHOLOGICAL ACTIVATION; DIFFERENTIATION; OLIGODENDROGLIOMA; TUMORS;
D O I
10.1177/1066896918800812
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Supratentorial ependymomas (ST EPNs) are molecularly characterized, of which the RELA fusion positive tumors are the most common and aggressive subgroup. Moreover, histologically, anaplastic ST EPN (ST-AE) often mimic other central nervous system primary high-grade tumors resulting in a diagnostic dilemma. We aimed to study a cohort of ST-AE; evaluate the expression of two RELA fusion-associated markers-L1CAM and p65 (NF-kappa B); and correlate their expression with clinical and histological parameters. Cases of ST-AE diagnosed in our department from January 2011 to June 2016 (n = 72) were reviewed. A battery of immunohistochemical markers was employed. A total of 65 confirmed ST-AE were included in the study. Age ranged from 9 months to 60 years. There was a slight predominance in the pediatric population (57%). Male-to-female ratio was 1:1.16. Histomorphological features were varied and mimicked other high-grade tumors in several cases. L1CAM immunopositive tumors constituted 26% of cases and were predominantly seen in young children, in the frontoparietal location, and exhibited clear cell morphology with calcification. A consistent pattern of L1CAM immunopositivity was noted in paired primary and recurrent tumor samples. Our study portrays the varied clinical and histomorphological spectrum of ST-AE. The study emphasizes the association of L1CAM immunopositivity with a wide spectrum of histological parameters, literature on which is scant till date. Since ST EPN-RELA are tumors with aggressive behavior, such a correlation would be clinically relevant, particularly when there is limited access to molecular testing.
引用
收藏
页码:251 / 258
页数:8
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