Endothelial Fatty Acid Transport: Role of Vascular Endothelial Growth Factor B

被引：59
作者：
Hagberg, Carolina [1 ]
Mehlem, Annika [1 ]
Falkevall, Annelie [1 ]
Muhl, Lars [1 ]
Eriksson, Ulf [1 ]
机构：
[1] Karolinska Inst, Stockholm, Sweden
来源：
PHYSIOLOGY | 2013年 / 28卷 / 02期
关键词：
VEGF-B; INSULIN-RESISTANCE; BINDING PROTEIN; METABOLIC-RESPONSES; TARGETED DELETION; LIPID-METABOLISM; TYROSINE KINASE; CELLULAR UPTAKE; CD36; MOUSE;
D O I：
10.1152/physiol.00042.2012
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Dietary lipids present in the circulation have to be transported through the vascular endothelium to be utilized by tissue cells, a vital mechanism that is still poorly understood. Vascular endothelial growth factor B (VEGF-B) regulates this process by controlling the expression of endothelial fatty acid transporter proteins (FATPs). Here, we summarize research on the role of the vascular endothelium in nutrient transport, with emphasis on VEGF-B signaling.
引用
收藏
页码：125 / 134
页数：10
相关论文
共 122 条
  • [61] PPARγ in the endothelium regulates metabolic responses to high-fat diet in mice
    Kanda, Takeshi
    Brown, Jonathan D.
    Orasanu, Gabriela
    Vogel, Silke
    Gonzalez, Frank J.
    Sartoretto, Juliano
    Michel, Thomas
    Plutzky, Jorge
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2009, 119 (01) : 110 - 124
  • [62] Overexpression of Vascular Endothelial Growth Factor-B in Mouse Heart Alters Cardiac Lipid Metabolism and Induces Myocardial Hypertrophy
    Karpanen, Terhi
    Bry, Maija
    Ollila, Hanna M.
    Seppanen-Laakso, Tuulikki
    Liimatta, Erkki
    Leskinen, Hanna
    Kivela, Riikka
    Helkamaa, Teemu
    Merentie, Mari
    Jeltsch, Michael
    Paavonen, Karri
    Andersson, Leif C.
    Mervaala, Eero
    Hassinen, Ilmo E.
    Yla-Herttuala, Seppo
    Oresic, Matej
    Alitalo, Kari
    [J]. CIRCULATION RESEARCH, 2008, 103 (09) : 1018 - U247
  • [63] Kawasaki T, 1999, DEVELOPMENT, V126, P4895
  • [64] Vascular Inflammation, Insulin Resistance, and Reduced Nitric Oxide Production Precede the Onset of Peripheral Insulin Resistance
    Kim, Francis
    Pham, Matilda
    Maloney, Ezekiel
    Rizzo, Norma O.
    Morton, Gregory J.
    Wisse, Brent E.
    Kirk, Elizabeth A.
    Chait, Alan
    Schwartz, Michael W.
    [J]. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2008, 28 (11) : 1982 - U142
  • [65] Obesity-associated improvements in metabolic profile through expansion of adipose tissue
    Kim, Ja-Young
    De Wall, Esther Van
    Laplante, Mathieu
    Azzara, Anthony
    Trujillo, Maria E.
    Hofmann, Susanna M.
    Schraw, Todd
    Durand, Jorge L.
    Li, Hua
    Li, Guangyu
    Jelicks, Linda A.
    Mehler, Mark F.
    Hui, David Y.
    Deshaies, Yves
    Shulman, Gerald I.
    Schwartz, Gary J.
    Scherer, Philipp E.
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2007, 117 (09) : 2621 - 2637
  • [66] Kim JK, 2004, J CLIN INVEST, V113, P756, DOI 10.1172/JCI200418917
  • [67] Mutations in the Fatty Acid Transport Protein 4 Gene Cause the Ichthyosis Prematurity Syndrome
    Klar, Joakim
    Schweiger, Martina
    Zimmerman, Robert
    Zechner, Rudolf
    Li, Hao
    Torma, Hans
    Vahlquist, Anders
    Bouadjar, Bakar
    Dahl, Niklas
    Fischer, Judith
    [J]. AMERICAN JOURNAL OF HUMAN GENETICS, 2009, 85 (02) : 248 - 253
  • [68] Impaired Insulin Signaling in Endothelial Cells Reduces Insulin-Induced Glucose Uptake by Skeletal Muscle
    Kubota, Tetsuya
    Kubota, Naoto
    Kumagai, Hiroki
    Yamaguchi, Shinichi
    Kozono, Hideki
    Takahashi, Takehiro
    Inoue, Mariko
    Itoh, Shinsuke
    Takamoto, Iseki
    Sasako, Takayoshi
    Kumagai, Katsuyoshi
    Kawai, Tomoko
    Hashimoto, Shinji
    Kobayashi, Tsuneo
    Sato, Maki
    Tokuyama, Kumpei
    Nishimura, Satoshi
    Tsunoda, Masaki
    Ide, Tomohiro
    Murakami, Koji
    Yamazaki, Tomomi
    Ezaki, Osamu
    Kawamura, Koichi
    Masuda, Hirotake
    Moroi, Masao
    Sugi, Kaoru
    Oike, Yuichi
    Shimokawa, Hiroaki
    Yanagihara, Nobuyuki
    Tsutsui, Masato
    Terauchi, Yasuo
    Tobe, Kazuyuki
    Nagai, Ryozo
    Kamata, Katsuo
    Inoue, Kenji
    Kodama, Tatsuhiko
    Ueki, Kohjiro
    Kadowaki, Takashi
    [J]. CELL METABOLISM, 2011, 13 (03) : 294 - 307
  • [69] Vascular Endothelial Growth Factor-B Induces Myocardium-Specific Angiogenesis and Arteriogenesis via Vascular Endothelial Growth Factor Receptor-1-and Neuropilin Receptor-1-Dependent Mechanisms
    Laehteenvuo, Johanna E.
    Laehteenvuo, Markku T.
    Kivelae, Antti
    Rosenlew, Carolina
    Falkevall, Annelie
    Klar, Joakim
    Heikura, Tommi
    Rissanen, Tuomas T.
    Vaehaekangas, Elisa
    Korpisalo, Petra
    Enholm, Berndt
    Carmeliet, Peter
    Alitalo, Kari
    Eriksson, Ulf
    Ylae-Herttuala, Seppo
    [J]. CIRCULATION, 2009, 119 (06) : 845 - U134
  • [70] Lazarus Alon, 2011, Proc Am Thorac Soc, V8, P508, DOI 10.1513/pats.201102-021MW
234567891011