Chemokines, cytokines and exosomes help tumors to shape inflammatory microenvironment

被引：99
作者：
Atretkhany, K. -S. N. [1 ,2 ]
Drutskaya, M. S. [1 ,2 ]
Nedospasov, S. A. [1 ,2 ,3 ]
Grivennikov, S. I. [1 ,4 ]
Kuprash, D. V. [1 ,2 ]
机构：
[1] Russian Acad Sci, Engelhardt Inst Mol Biol, Vavilova Str 32, Moscow 119991, Russia
[2] Lomonosov Moscow State Univ, Fac Biol, Moscow 119234, Russia
[3] German Rheumatol Res Ctr DRFZ, Berlin, Germany
[4] Fox Chase Canc Ctr, Canc Prevent & Control Program, 7701 Burholme Ave, Philadelphia, PA 19111 USA
来源：
PHARMACOLOGY & THERAPEUTICS | 2016年 / 168卷
基金：
俄罗斯科学基金会;
关键词：
Inflammation; Tumor; Cancer; Chemokines; Cytokines; Exosomes; REGULATORY T-CELLS; ENDOTHELIAL GROWTH-FACTOR; NF-KAPPA-B; NECROSIS-FACTOR-ALPHA; INTERLEUKIN-17 PROMOTES ANGIOGENESIS; LYMPH-NODE METASTASIS; TOLL-LIKE RECEPTORS; BREAST-CANCER; SUPPRESSOR-CELLS; MYELOID CELLS;
D O I：
10.1016/j.pharmthera.2016.09.011
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Relationship between inflammation and cancer is now well-established and represents a paradigm that our immune response does not necessarily serves solely to protect us from infections and cancer. Many specific mechanisms that link chronic inflammation to cancer promotion and metastasis have been uncovered in the recent years. Here we are focusing on the effects that tumors may exert on inflammatory cascades, tuning the immune system ability to cause tumor promotion or regression. In particular, we discuss the contributions of chemokines, cytokines and exosomes to the processes such as induction of inflammation and tumorigenesis. Overall, tumor-elicited inflammation is a key driver of tumor progression and an essential component of tumor microenvironment. (C) 2016 Elsevier Inc. All rights reserved.
引用
收藏
页码：98 / 112
页数：15
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