Photosensitization of DNA by 5-Methyl-2-Pyrimidone Deoxyribonucleoside: (6-4) Photoproduct as a Possible Trojan Horse

被引：32
作者：
Vendrell-Criado, Victoria [1 ]
Rodriguez-Muniz, Gemma M. [1 ]
Consuelo Cuquerella, M. [1 ]
Lhiaubet-Vallet, Virginie [1 ]
Miranda, Miguel A. [1 ]
机构：
[1] Univ Politecn Valencia, CSIC, Inst Tecnol Quim, Valencia 46022, Spain
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 25期
关键词：
cyclobutane pyrimidine dimers; DNA damage; photochemistry; pyrimidones; triplet excited states; CYCLOBUTANE PYRIMIDINE DIMER; NUCLEIC-ACID COMPONENTS; 2-PYRIMIDINONE NUCLEOSIDES; PHOTOLYASE; MECHANISM; REPAIR; DYNAMICS; DAMAGE; MUTAGENESIS; THYMINE;
D O I：
10.1002/anie.201302176
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A (photo)sensitive subject: Combined agarose gel electrophoresis and photochemical studies show that 5-methyl-2-pyrimidone (see picture), the main chromophore of (6-4) photoproducts, behaves as a DNA photosensitizer. These results raise the question of whether the (6-4) lesions can act as Trojan horses, enhancing cyclobutane pyrimidine dimer (CPD) formation and oxidative damage. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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收藏
页码：6476 / 6479
页数：4
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