Complete genome sequence of Treponema pallidum strain DAL-1

被引：34

作者：

Zobanikova, Marie ^{[1
]}

Mikolka, Pavol ^{[1
]}

Cejkova, Darina ^{[1
,2
,3
]}

Pospisilova, Petra ^{[1
,2
]}

Chen, Lei ^{[2
,3
]}

Strouhal, Michal ^{[1
,3
]}

Qin, Xiang ^{[2
]}

Weinstock, George M. ^{[2
,3
]}

Smajs, David ^{[1
]}

机构：

[1] Masaryk Univ, Fac Med, Dept Biol, Brno, Czech Republic

[2] Baylor Coll Med, Human Genome Sequencing Ctr, Houston, TX 77030 USA

[3] Washington Univ, Sch Med, Dept Genet, Genome Inst, St Louis, MO 63110 USA

来源：

STANDARDS IN GENOMIC SCIENCES | 2012年 / 7卷 / 01期

关键词：

Spirochaetaceae; Treponema pallidum; syphilis; SYPHILIS; GENE; DIVERSITY; TISSUE; TPRK; CULTIVATION; INFECTION; PERTENUE; BACTERIA; MUTATION;

D O I：

10.4056/sigs.2615838

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Treponema pallidum strain DAL-1 is a human uncultivable pathogen causing the sexually transmitted disease syphilis. Strain DAL-1 was isolated from the amniotic fluid of a pregnant woman in the secondary stage of syphilis. Here we describe the 1,139,971 bp long genome of T. pallidum strain DAL-1 which was sequenced using two independent sequencing methods (454 pyrosequencing and Illumina). In rabbits, strain DAL-1 replicated better than the T. pallidum strain Nichols. The comparison of the complete DAL-1 genome sequence with the Nichols sequence revealed a list of genetic differences that are potentially responsible for the increased rabbit virulence of the DAL-1 strain.

引用

页码：12 / 21

页数：10

共 46 条

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