Investigation of microporous composite scaffolds fabricated by embedding sacrificial polyethylene glycol microspheres in nanofibrous membrane

被引：18
作者：
Gao, Junjiu [1 ,2 ]
Zhu, Jiang [1 ,2 ]
Luo, Jingjing [1 ,3 ]
Xiong, Jie [1 ,2 ]
机构：
[1] Zhejiang Sci Tech Univ, Coll Mat & Text, Hangzhou 310018, Zhejiang, Peoples R China
[2] Zhejiang Sci Tech Univ, Minist Educ, Key Lab Adv Text Mat & Mfg Technol, Hangzhou 310018, Zhejiang, Peoples R China
[3] Zhejiang Sci Tech Univ, Coll Life Sci, Hangzhou 310018, Zhejiang, Peoples R China
来源：
COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING | 2016年 / 91卷
基金：
中国国家自然科学基金;
关键词：
Nano-structures; Polymer-matrix composites (PMCs); Porosity; Electrospinning; SILK FIBROIN; IN-VITRO;
D O I：
10.1016/j.compositesa.2016.09.015
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
The application of electrospun nanofibrous scaffolds in tissue engineering is limited due to their small pore size which leads to the failure of cell infiltration into the scaffolds. Microporous silk fibroin (SF)/gelatin composite scaffolds with biological properties could be fabricated to mimic tissue structure for tissue engineering applications. This study aimed to present a simple method to fabricate the composite scaffolds which is based on the simultaneously electrospraying of microspheres and electrospinning of nano fibers. Different contents of polyethylene glycol (PEG) microspheres were embedded into the SF/gelatin nanofibrous membranes by varying the content of PEG microsphere. Furthermore, microspheres can be selectively leached, obtaining the single SF/gelatin nanofibrous scaffolds and retaining the hierarchical organization of the porous nanofibers. In conclusion, the multilevel microporous and nanofibrous composite scaffolds can be obtained by varying pump flow rate of electrospraying. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码：20 / 29
页数：10
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