Endocrine Significance of SARS-CoV-2's Reliance on ACE2

被引：131

作者：

Lazartigues, Eric ^{[1
,2
,3
]}

Qadir, Mirza Muhammad Fahd ^{[3
,4
]}

Mauvais-Jarvis, Franck ^{[3
,4
]}

机构：

[1] Dept Pharmacol & Expt Therapeut, New Orleans, LA USA

[2] Louisiana State Univ, Hlth Sci Ctr, Cardiovasc Ctr Excellence, New Orleans, LA 70112 USA

[3] Southeast Louisiana Vet Hlth Care Syst, New Orleans, LA 70119 USA

[4] Tulane Univ, Dept Med, Div Endocrinol & Metab, Sch Med, New Orleans, LA 70112 USA

来源：

ENDOCRINOLOGY | 2020年 / 161卷 / 09期

基金：

美国国家卫生研究院;

关键词：

renin-angiotensin system; ACE2; TMPRSS-2; SARS-CoV-2; COVID-19; diabetes; ANGIOTENSIN-CONVERTING ENZYME; OBESITY-HYPERTENSION; PANCREATIC-ISLETS; SARS CORONAVIRUS; GENE-THERAPY; EXPRESSION; TARGET; BRAIN; ANGIOTENSIN-CONVERTING-ENZYME-2; OVEREXPRESSION;

D O I：

10.1210/endocr/bqaa108

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The current COVID-19 pandemic is the most disruptive event in the past 50 years, with a global impact on health care and world economies. It is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), a coronavirus that uses angiotensin-converting enzyme 2 (ACE2) as an entry point to the cells. ACE2 is a transmembrane carboxypeptidase and member of the renin-angiotensin system. This mini-review summarizes the main findings regarding ACE2 expression and function in endocrine tissues. We discuss rapidly evolving knowledge on the potential role of ACE2 and SARS coronaviruses in endocrinology and the development of diabetes mellitus, hypogonadism, and pituitary and thyroid diseases.

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页数：7

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