Evidence of persistent central sensitization in chronic headaches: a multi-method study

被引：107

作者：

Filatova, Elena ^{[1
,2
]}

Latysheva, Nina ^{[1
]}

Kurenkov, Alexey ^{[1
,2
,3
]}

机构：

[1] Alexander Vein Headache Clin, Moscow 125040, Russia

[2] Sechenov Moscow Med Acad, Moscow, Russia

[3] Res Ctr Childrens Hlth, Moscow, Russia

来源：

JOURNAL OF HEADACHE AND PAIN | 2008年 / 9卷 / 05期

关键词：

Allodynia; Chronic headache; Central sensitization; Pressure algometry; Electrophysiology;

D O I：

10.1007/s10194-008-0061-7

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The aim of this study was to investigate central sensitization (CS) in chronic headaches and compare this phenomenon between chronic migraine (CM) and chronic tension-type headache (CTTH). We recruited 69 patients with chronic headaches and 18 control subjects. Questionnaires of headache history, allodynia and the Hospital Anxiety and Depression scale were administered. We recorded thresholds for pinprick and pressure pain, blink (BR) and nociceptive flexion reflex (NFR) R3 component coupled with wind-up ratios. Thresholds for pressure and pinprick pain, BR and NFR R3 were lower and wind-up ratios higher in patients. No differences of CS parameters between CM and CTTH were observed. CS is persistent and prevalent in patients with various types of chronic headache. CS levels are unrelated to the predominant side of pain, disease duration or depression. Neither is CS related to the headache type, suggesting similar mechanisms of headache chronification and chronicity maintaining and possibly explaining clinical similarity of various forms of chronic headache.

引用

页码：295 / 300

页数：6

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