Brain metastasis in non-small cell lung cancer (NSCLC) patients with uncommon EGFR mutations: a report of seven cases and literature review

被引：4

作者：

Er, Puchun

Zhang, Tian

Wang, Jing

Pang, Qingsong ^{[1
]}

Wang, Ping ^{[1
]}

机构：

[1] Tianjin Med Univ Canc Inst & Hosp, Dept Radiotherapy, Tianjin, Peoples R China

来源：

CANCER BIOLOGY & MEDICINE | 2017年 / 14卷 / 04期

关键词：

TYROSINE KINASE INHIBITORS; FACTOR RECEPTOR MUTATIONS; RADIATION-THERAPY; GEFITINIB; RADIOTHERAPY; TKIS; ERLOTINIB; EFFICACY; AFATINIB; IMPACT;

D O I：

10.20892/j.issn.2095-3941.2017.0079

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Brain metastasis (BM) arising from non-small cell lung cancer (NSCLC) with rare epidermal growth factor receptor (EGFR) mutations is quite rare. The prognosis and therapeutic effects of BM remain enigmatic. To the best of our knowledge, this is the first report to make a separate analysis of BM from NSCLC patients with original uncommon EGFR mutations. We retrospectively reviewed 7 cases of BM arising from 42 cases of uncommon EGFR mutated lung cancer in Tianjin Medical University Cancer Institute and Hospital. We also performed a literature review to assess therapeutic features and outcomes.

引用

收藏

页码：418 / 425

页数：8

相关论文

共 39 条

[21] Management of Brain Metastases in Tyrosine Kinase Inhibitor-Naive Epidermal Growth Factor Receptor-Mutant Non-Small-Cell Lung Cancer: A Retrospective Multi-Institutional Analysis [J].

Magnuson, William J. ;

Lester-Coll, Nataniel H. ;

Wu, Abraham J. ;

Yang, T. Jonathan ;

Lockney, Natalie A. ;

Gerber, Naamit K. ;

Beal, Kathryn ;

Amini, Arya ;

Patil, Tejas ;

Kavanagh, Brian D. ;

Camidge, D. Ross ;

Braunstein, Steven E. ;

Boreta, Lauren C. ;

Balasubramanian, Suresh K. ;

Ahluwalia, Manmeet S. ;

Rana, Niteshkumar G. ;

Attia, Albert ;

Gettinger, Scott N. ;

Contessa, Joseph N. ;

Yu, James B. ;

Chiang, Veronica L. .

JOURNAL OF CLINICAL ONCOLOGY, 2017, 35 (10) :1070-+

[22] Impact of Deferring Radiation Therapy in Patients With Epidermal Growth Factor Receptor-Mutant Non-Small Cell Lung Cancer Who Develop Brain Metastases [J].

Magnuson, William J. ;

Yeung, Jacky T. ;

Guillod, Paul D. ;

Gettinger, Scott N. ;

Yu, James B. ;

Chiang, Veronica L. .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2016, 95 (02) :673-679

[23] Uncommon Epidermal Growth Factor Receptor mutations in non-small cell lung cancer and their mechanisms of EGFR tyrosine kinase inhibitors sensitivity and resistance [J].

Massarelli, Erminia ;

Johnson, Faye M. ;

Erickson, Heidi S. ;

Wistuba, Ignacio I. ;

Papadimitrakopoulou, Vassiliki .

LUNG CANCER, 2013, 80 (03) :235-241

[24] High efficacy of third generation EGFR inhibitor AZD9291 in a leptomeningeal carcinomatosis model with EGFR-mutant lung cancer cells [J].

Nanjo, Shigeki ;

Ebi, Hiromichi ;

Arai, Sachiko ;

Takeuchi, Shinji ;

Yamada, Tadaaki ;

Mochizuki, Satsuki ;

Okada, Yasunori ;

Nakada, Mitsutoshi ;

Murakami, Takashi ;

Yano, Seiji .

ONCOTARGET, 2016, 7 (04) :3847-3856

[25]

Noronha Vanita, 2014, Chemother Res Pract, V2014, P856156, DOI 10.1155/2014/856156

[26] The Value of the History and Physical for Patients with Newly Diagnosed Brain Metastases Considering Radiosurgery [J].

Paydar, Ima ;

Oermann, Eric Karl ;

Knoll, Miriam ;

Lee, James ;

Collins, Brian Timothy ;

Ewend, Matthew ;

Kondziolka, Douglas ;

Collins, Sean P. .

FRONTIERS IN ONCOLOGY, 2016, 6

[27] Multimodality management of non-small cell lung cancer patients with brain metastases [J].

Ricciardi, Serena ;

de Marinis, Filippo .

CURRENT OPINION IN ONCOLOGY, 2010, 22 (02) :86-93

[28] Erlotinib plus concurrent whole-brain radiation therapy for non-small cell lung cancers patients with multiple brain metastases [J].

Ulahannan, Danny ;

Lee, Siow-Ming .

TRANSLATIONAL LUNG CANCER RESEARCH, 2016, 5 (02) :208-211

[29] Effectiveness of Gefitinib against Non-Small-Cell Lung Cancer with the Uncommon EGFR Mutations G719X and L861Q [J].

Watanabe, Satoshi ;

Minegishi, Yuji ;

Yoshizawa, Hirohisa ;

Maemondo, Makoto ;

Inoue, Akira ;

Sugawara, Shunichi ;

Isobe, Hiroshi ;

Harada, Masao ;

Ishii, Yoshiki ;

Gemma, Akihiko ;

Hagiwara, Koichi ;

Kobayashi, Kunihiko .

JOURNAL OF THORACIC ONCOLOGY, 2014, 9 (02) :189-194

[30] Prognostic factors analysis in EGFR mutation-positive non-small cell lung cancer with brain metastases treated with whole brain-radiotherapy and EGFR-tyrosine kinase inhibitors [J].

Wei, Hangping ;

Su, Meng ;

Lin, Ruifang ;

Li, Huifang ;

Zou, Changlin .

ONCOLOGY LETTERS, 2016, 11 (03) :2249-2254

← 1 2 3 4 →