Brain metastasis in non-small cell lung cancer (NSCLC) patients with uncommon EGFR mutations: a report of seven cases and literature review

被引：4
作者：
Er, Puchun
Zhang, Tian
Wang, Jing
Pang, Qingsong [1 ]
Wang, Ping [1 ]
机构：
[1] Tianjin Med Univ Canc Inst & Hosp, Dept Radiotherapy, Tianjin, Peoples R China
来源：
CANCER BIOLOGY & MEDICINE | 2017年 / 14卷 / 04期
关键词：
TYROSINE KINASE INHIBITORS; FACTOR RECEPTOR MUTATIONS; RADIATION-THERAPY; GEFITINIB; RADIOTHERAPY; TKIS; ERLOTINIB; EFFICACY; AFATINIB; IMPACT;
D O I：
10.20892/j.issn.2095-3941.2017.0079
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Brain metastasis (BM) arising from non-small cell lung cancer (NSCLC) with rare epidermal growth factor receptor (EGFR) mutations is quite rare. The prognosis and therapeutic effects of BM remain enigmatic. To the best of our knowledge, this is the first report to make a separate analysis of BM from NSCLC patients with original uncommon EGFR mutations. We retrospectively reviewed 7 cases of BM arising from 42 cases of uncommon EGFR mutated lung cancer in Tianjin Medical University Cancer Institute and Hospital. We also performed a literature review to assess therapeutic features and outcomes.
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收藏
页码：418 / 425
页数：8
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