Decreased Functional Connectivity by Aging Is Associated with Cognitive Decline

被引：262

作者：

Onoda, Keiichi ^{[1
]}

Ishihara, Masaki ^{[1
]}

Yamaguchi, Shuhei ^{[1
]}

机构：

[1] Shimane Univ, Dept Neurol, 89-1 Enya Cho, Izumo, Shimane 6938501, Japan

来源：

JOURNAL OF COGNITIVE NEUROSCIENCE | 2012年 / 24卷 / 11期

关键词：

RESTING-STATE NETWORKS; DEFAULT-MODE NETWORK; ANTERIOR CINGULATE CORTEX; INDEPENDENT COMPONENT ANALYSIS; FRONTAL ASSESSMENT BATTERY; ALZHEIMERS-DISEASE; SUBGENUAL CINGULATE; NEURAL MECHANISMS; BRAIN ACTIVITY; SOCIAL PAIN;

D O I：

10.1162/jocn_a_00269

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Aging is related to cognitive decline, and it has been reported that aging disrupts some resting state brain networks. However, most studies have focused on the default mode network and ignored other resting state networks. In this study, we measured resting state activity using fMRI and explored whether cognitive decline with aging is related to disrupted resting state networks. Independent component analysis was used to evaluate functional connectivity. Notably, the connectivity within the salience network that consisted of the bilateral insula and the anterior cingulated cortex decreased with aging; the impairment of functional connectivity was correlated with measured decreases in individual cognitive abilities. Furthermore, certain internetwork connectivities (salience to auditory, default mode to visual, etc.) also decreased with aging. These results suggest that (1) aging affects not only the default mode network but also other networks, specifically the salience network; (2) aging affects internetwork connectivity; and (3) disruption of the salience network is related to cognitive decline in elderly people.

引用

页码：2186 / 2198

页数：13

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