Biosynthesis of the heat-shock protein 90 inhibitor geldanamycin: New insight into the formation of the benzoquinone moiety

被引：31

作者：

Lee, DH

Lee, K

Cai, F

Dat, NT

Boovanahalli, SK

Lee, M

Shin, JC

Kim, W

Jeong, JK

Lee, JS

Lee, CH

Lee, JH

Hong, YS ^{[1
]}

Lee, JJ

机构：

[1] Korea Res Inst Biosci & Biotechnol, Lab Anticanc Agents, Taejon 305333, South Korea

[2] Korea Res Inst Biosci & Biotechnol, Lab Immune Modulators, Taejon 305333, South Korea

来源：

CHEMBIOCHEM | 2006年 / 7卷 / 02期

关键词：

antitumor agents; autooxidation; biosynthesis; polyketides;

D O I：

10.1002/cbic.200500441

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A clue towards determining the biosynthetic origin of ansamycin benzoquinone formation by spontaneous oxidation from a corresponding hydroquinone has been provided by ACDL3172 (1), a tricyclic geldanamycin derivative produced by the gel8 gene-inactivated strain of S. hygroscopicus subsp. duamyceticus JCM4427. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

收藏

页码：246 / 248

页数：3

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