Biosynthesis of the heat-shock protein 90 inhibitor geldanamycin: New insight into the formation of the benzoquinone moiety

被引：31
作者：
Lee, DH
Lee, K
Cai, F
Dat, NT
Boovanahalli, SK
Lee, M
Shin, JC
Kim, W
Jeong, JK
Lee, JS
Lee, CH
Lee, JH
Hong, YS [1 ]
Lee, JJ
机构：
[1] Korea Res Inst Biosci & Biotechnol, Lab Anticanc Agents, Taejon 305333, South Korea
[2] Korea Res Inst Biosci & Biotechnol, Lab Immune Modulators, Taejon 305333, South Korea
来源：
CHEMBIOCHEM | 2006年 / 7卷 / 02期
关键词：
antitumor agents; autooxidation; biosynthesis; polyketides;
D O I：
10.1002/cbic.200500441
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A clue towards determining the biosynthetic origin of ansamycin benzoquinone formation by spontaneous oxidation from a corresponding hydroquinone has been provided by ACDL3172 (1), a tricyclic geldanamycin derivative produced by the gel8 gene-inactivated strain of S. hygroscopicus subsp. duamyceticus JCM4427. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.
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收藏
页码：246 / 248
页数：3
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