Preparation of Functionalized Organoindium Reagents by Means of Magnesium Insertion into Organic Halides in the Presence of InCl3 at Room Temperature

被引：29

作者：

Bernhardt, Sebastian ^{[1
]}

Shen, Zhi-Liang ^{[1
]}

Knochel, Paul ^{[1
]}

机构：

[1] Univ Munich, Dept Chem, D-81377 Munich, Germany

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2013年 / 19卷 / 03期

基金：

欧洲研究理事会;

关键词：

cross-coupling; indium; insertion; magnesium; palladium; CROSS-COUPLING REACTIONS; LICL-MEDIATED PREPARATION; INDIUM ORGANOMETALLICS; TRIORGANOINDIUM REAGENTS; ARYLINDIUM REAGENTS; CATALYZED-REACTIONS; CARBON-CARBON; ARYL; ZINC; ALUMINUM;

D O I：

10.1002/chem.201203795

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Magnesium, indium, palladium: An efficient one-pot procedure for the direct preparation of triorganoindium reagents from organic halides by means of magnesium insertion in the presence of InCl3 and LiCl is reported (see scheme). The organoindium reagents are obtained in good yields from functionalized aryl, heteroaryl, and alkyl bromides and benzyl chlorides at 25 °C in THF within 4h. Moreover, the resulting organoindium reagents could be efficiently used as reagents in Pd-catalyzed cross-coupling reactions with a wide functional group tolerance. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：828 / 833

页数：6

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