Palladium-Catalyzed Intermolecular C3 Alkenylation of Indoles Using Oxygen as the Oxidant

被引：110

作者：

Chen, Wen-Liang

Gao, Ya-Ru

Mao, Shuai

Zhang, Yan-Lei

Wang, Yu-Fei

Wang, Yong-Qiang ^{[1
]}

机构：

[1] NW Univ Xian, Key Lab Synthet & Nat Funct Mol Chem, Minist Educ, Dept Chem & Mat Sci, Xian 710069, Peoples R China

来源：

ORGANIC LETTERS | 2012年 / 14卷 / 23期

基金：

中国国家自然科学基金;

关键词：

ACTIVE CARBAZOLE ALKALOIDS; H BOND FUNCTIONALIZATION; DIELS-ALDER REACTION; BIOLOGICAL EVALUATION; OLEFINATION; PYRROLES; 3-VINYLINDOLES; DERIVATIVES; VINYLATION; CHALCONES;

D O I：

10.1021/ol302840b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A general and efficient palladium-catalyzed intermolecular direct C3 alkenylation of indoles using oxygen as the oxidant has been developed. The reaction is of complete regio- and stereoselectivity. All products are E-isomers at the C3-position, and no Z-isomers or 2-substituted product can be detected.

引用

页码：5920 / 5923

页数：4

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