Stretch-Induced Biodegradation of Polyelectrolyte Multilayer Films for Drug Release

被引：36
作者：
Barthes, Julien [2 ,3 ]
Mertz, Damien [2 ,3 ]
Bach, Charlotte [2 ,3 ]
Metz-Boutigue, Marie-Helene [2 ,3 ]
Senger, Bernard [2 ,3 ]
Voegel, Jean-Claude [2 ,3 ]
Schaaf, Pierre [1 ]
Lavalle, Philippe [2 ,3 ]
机构：
[1] Inst Charles Sadron, CNRS, UPR22, F-67034 Strasbourg 2, France
[2] Inst Natl Sante & Rech Med, INSERM, U977, F-67085 Strasbourg, France
[3] Univ Strasbourg, Fac Chirurg Dentaire, F-67000 Strasbourg, France
来源：
LANGMUIR | 2012年 / 28卷 / 38期
关键词：
DELIVERY;
D O I：
10.1021/la302550q
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The design of stimuli-responsive polymer assemblies for the controlled release of bioactive molecules has raised considerable interest these two last decades. Herein, we report the design of mechanically responsive drug-releasing films made of polyelectrolyte multilayers. A layer-by-layer (LbL) reservoir containing biodegradable polyelectrolytes is capped with a mechanosensitive LbL barrier and responds to stretching by a total enzymatic degradation of the film. This strategy is successfully applied for the release in solution of an anticancer drug initially loaded within the architecture.
引用
收藏
页码：13550 / 13554
页数：5
相关论文
共 22 条
  • [1] Responsive polymers in controlled drug delivery
    Bajpai, A. K.
    Shukla, Sandeep K.
    Bhanu, Smitha
    Kankane, Sanjana
    [J]. PROGRESS IN POLYMER SCIENCE, 2008, 33 (11) : 1088 - 1118
  • [2] Nanoengineering of inorganic and hybrid hollow spheres by colloidal templating
    Caruso, F
    Caruso, RA
    Möhwald, H
    [J]. SCIENCE, 1998, 282 (5391) : 1111 - 1114
  • [3] Cyto-mechanoresponsive Polyelectrolyte Multilayer Films
    Davila, Johanna
    Chassepot, Armelle
    Longo, Johan
    Boulmedais, Fouzia
    Reisch, Andreas
    Frisch, Benoit
    Meyer, Florent
    Voegel, Jean-Claude
    Mesini, Philippe J.
    Senger, Bernard
    Metz-Boutigue, Marie-Helene
    Hemmerle, Joseph
    Lavalle, Philippe
    Schaaf, Pierre
    Jierry, Loic
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2012, 134 (01) : 83 - 86
  • [4] Fuzzy nanoassemblies: Toward layered polymeric multicomposites
    Decher, G
    [J]. SCIENCE, 1997, 277 (5330) : 1232 - 1237
  • [5] Decher G., 2003, MULTILAYER THIN FILM
  • [6] Mechanically responsive films of variable hydrophobicity made of polyelectrolyte multilayers
    Hemmerlé, J
    Roucoules, V
    Fleith, G
    Nardin, M
    Ball, V
    Lavalle, P
    Marie, P
    Voegel, JC
    Schaaf, P
    [J]. LANGMUIR, 2005, 21 (23) : 10328 - 10331
  • [7] Salt-induced polyelectrolyte interdiffusion in multilayered films: A neutron reflectivity study
    Jomaa, HW
    Schlenoff, JB
    [J]. MACROMOLECULES, 2005, 38 (20) : 8473 - 8480
  • [8] Multilayered polyelectrolyte films: a tool for arteries and vessel repair
    Kerdjoudj, Halima
    Berthelemy, Nicolas
    Boulmedais, Fouzia
    Stoltz, Jean-Francois
    Menu, Patrick
    Voegel, Jean Claude
    [J]. SOFT MATTER, 2010, 6 (16) : 3722 - 3734
  • [9] Layer-by-Layer Hydrogen-Bonded Polymer Films: From Fundamentals to Applications
    Kharlampieva, Eugenia
    Kozlovskaya, Veronika
    Sukhishvili, Svetlana A.
    [J]. ADVANCED MATERIALS, 2009, 21 (30) : 3053 - 3065
  • [10] Cremophor reduces paclitaxel penetration into bladder wall during intravesical treatment
    Knemeyer, I
    Wientjes, MG
    Au, JLS
    [J]. CANCER CHEMOTHERAPY AND PHARMACOLOGY, 1999, 44 (03) : 241 - 248
123