Advances in the Genetics and Biology of Pancreatic Cancer

被引：20

作者：

Aguirre, Andrew J. ^{[1
]}

Collisson, Eric A. ^{[2
]}

机构：

[1] Dana Farber Canc Inst, Boston, MA 02115 USA

[2] Univ Calif San Francisco, Dept Med, Helen Diller Comprehens Canc Ctr, 1450 3rd St, San Francisco, CA 94143 USA

来源：

CANCER JOURNAL | 2017年 / 23卷 / 06期

基金：

美国国家卫生研究院;

关键词：

Cancer; pancreatic cancer; pancreatic ductal adenocarcinoma (PDA); PDA biology; PDA genetics; ANABOLIC GLUCOSE-METABOLISM; CIRCULATING TUMOR-CELLS; KRAS-DRIVEN CANCERS; DUCTAL ADENOCARCINOMA; ONCOGENIC KRAS; MUTANT KRAS; MEK INHIBITOR; DISTANT METASTASIS; GENOMIC ANALYSES; UNITED-STATES;

D O I：

10.1097/PPO.0000000000000286

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Pancreatic ductal adenocarcinoma (PDA) remains one of the most devastating diagnoses in modern medicine. While the clinical management of the disease has improved, the complex biologic underpinnings of PDA enable both its aggressive nature and slow clinical translational progress. In this review, we provide an overview of the key features of PDA genetics and biology, highlighting translational challenges and providing a framework for improved diagnostic and therapeutic approaches.

引用

页码：315 / 320

页数：6

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