Validity of a maternal alcohol consumption questionnaire in detecting prenatal exposure

被引：23

作者：

Manich, A. ^{[1
]}

Velasco, M. ^{[1
]}

Joya, X. ^{[1
]}

Garcia-Lara, N. R. ^{[2
]}

Pichini, S. ^{[3
]}

Vall, O. ^{[1
]}

Garcia-Algar, O. ^{[1
]}

机构：

[1] IMIM Hosp Mar, URIE, Serv Pediat, Red SAMID, Barcelona, Spain

[2] Hosp 12 Octubre, Serv Neonatol, Red SAMID, Madrid, Spain

[3] Ist Super Sanita, Drug Res & Evaluat Dept, I-00161 Rome, Italy

来源：

ANALES DE PEDIATRIA | 2012年 / 76卷 / 06期

关键词：

Alcohol; Biomarkers; Newborn; Meconium; Pregnancy; Prenatal exposure; Questionnaire; ACID ETHYL-ESTERS; MEDITERRANEAN CITY; MECONIUM; PREVALENCE; DRINKING; GLUCURONIDE; POPULATION; BIOMARKERS; SULFATE;

D O I：

10.1016/j.anpedi.2011.09.016

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Introduction: Ethanol consumption by pregnant women can produce severe effects in the foetus and the newborn, mainly in neurological and weight-height development, and are included in the term FASD (Fetal Alcohol Spectrum Disorder). Questionnaires are the most used screening method to detect prenatal exposure, but a previous population study questioned its reliability. The objective of this study was to compare alcohol prenatal exposure detection by questionnaire compared with biomarkers in meconium. Methodology: Sixty two meconium samples from mothers who denied alcohol consumption during pregnancy by questionnaire were analysed. The objective analysis was made by determination of FAEEs (fatty acid ethyl esters) as exposure biomarkers in meconium as biological matrix. Results: In the meconium from 10 of 62 newborns from non-alcohol consuming mothers by questionnaire (16.12%) FAEE values were positive (>= 2 nmol/g). Discussion: Questionnaires as a screening method during pregnancy are not a reliable tool. It is necessary to identify prenatal exposure to alcohol as soon as possible by biomarkers analysis in biological matrices from the newborn or the mother. The early detection will allow these patients to benefit from follow up and treatment to reach the best possible neurological development. (C) 2011 Asociacion Espanola de Pediatria. Published by Elsevier Espana, S.L. All rights reserved.

引用

页码：324 / 328

页数：5

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