Presence of kynurenic acid in food and honeybee products

被引：98

作者：

Turski, Michal P. ^{[1
]}

Turska, Monika ^{[1
]}

Zgrajka, Wojciech ^{[1
]}

Kuc, Damian ^{[2
]}

Turski, Waldemar A. ^{[1
,2
]}

机构：

[1] Inst Agr Med, Dept Toxicol, PL-20950 Lublin, Poland

[2] Med Univ, Dept Expt & Clin Pharmacol, PL-20090 Lublin, Poland

来源：

AMINO ACIDS | 2009年 / 36卷 / 01期

关键词：

Kynurenic acid; Food; Honeybee product; Digestive system; Absorption; RAT-BRAIN; FLUID; NMDA;

D O I：

10.1007/s00726-008-0031-z

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Kynurenic acid (KYNA) is an endogenous antagonist of ionotropic glutamate receptors and the alpha 7 nicotinic acetylcholine receptor, showing anticonvulsant and neuroprotective activity. In this study, the presence of KYNA in food and honeybee products was investigated. KYNA was found in all 37 tested samples of food and honeybee products. The highest concentration of KYNA was obtained from honeybee products' samples, propolis (9.6 nmol/g), honey (1.0-4.8 nmol/g) and bee pollen (3.4 nmol/g). A high concentration was detected in fresh broccoli (2.2 nmol/g) and potato (0.7 nmol/g). Only traces of KYNA were found in some commercial baby products. KYNA administered intragastrically in rats was absorbed from the intestine into the blood stream and transported to the liver and to the kidney. In conclusion, we provide evidence that KYNA is a constituent of food and that it can be easily absorbed from the digestive system.

引用

页码：75 / 80

页数：6

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