Chronic morphine increases biosynthesis of nitric oxide synthase in the rat spinal cord

被引:63
|
作者
Machelska, H [1 ]
Ziolkowska, B [1 ]
Mika, J [1 ]
Przewlocka, B [1 ]
Przewlocki, R [1 ]
机构
[1] POLISH ACAD SCI,INST PHARMACOL,DEPT MOL NEUROPHARMACOL,PL-31343 KRAKOW,POLAND
关键词
morphine tolerance; nitric oxide; nitric oxide synthase; nitric oxide synthase mRNA; nitric oxide synthase immunoreactivity; rat; spinal cord;
D O I
10.1097/00001756-199708180-00020
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
THE present study was undertaken to determine the influence of chronic morphine treatment on the biosynthesis of nitric oxide synthase (NOS) in the rat spinal cord using in situ hybridization and immunohistochemical methods. Repeated administration of morphine (20-100 mg/kg/day; 10 days) increased the NOS mRNA level in laminae I-IV and X 3 h after the last injection. That effect was accompanied by an increase in both the number of NOS-positive cells (24h) and the optical density of NOS-immunoreactivity (3 and 24h). The results indicate that repeated morphine administration increases NOS biosynthesis in the rat spinal cord, which may reflect adaptive changes accounting for development of opiate tolerance and dependence.
引用
收藏
页码:2743 / 2747
页数:5
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