Oral squamous cell carcinomas in age distinct population: A comparison of p53 immunoexpression

被引：5

作者：

Chandra, Akhilesh ^{[1
,2
]}

Singh, Anil ^{[3
]}

Sebastian, Bastian Thattil ^{[4
]}

Agnihotri, Archana ^{[5
]}

Bali, Ruchita ^{[6
]}

Verma, Pushpendra Kumar ^{[7
]}

机构：

[1] Banaras Hindu Univ, Inst Med Sci, Dept Oral Pathol, Fac Dent Sci, Varanasi 221005, Uttar Pradesh, India

[2] Banaras Hindu Univ, Inst Med Sci, Dept Maxillofacial Pathol, Fac Dent Sci, Varanasi 221005, Uttar Pradesh, India

[3] Sardar Patel Post Grad Inst Dent & Med Sci, Lucknow, Uttar Pradesh, India

[4] Mahe Inst Dent Sci & Hosp, Mahe, Puducherry, India

[5] Coll Dent, Azamgarh, India

[6] Shree Bankey Bihari Dent Coll & Res Ctr, Ghaziabad, India

[7] Banaras Hindu Univ, Inst Med Sci, Fac Dent Sci, Dept Conservat Dent & Endodont, Varanasi 221005, Uttar Pradesh, India

来源：

JOURNAL OF CANCER RESEARCH AND THERAPEUTICS | 2013年 / 9卷 / 04期

关键词：

Immunohistochemistry; p53; protein; oral squamous cell carcinoma; ANTIGEN RETRIEVAL; PATIENTS YOUNGER; TONGUE CANCER; RISK-FACTORS; EXPRESSION; KI-67; PROTEIN; NONSMOKING; PATTERNS; LESIONS;

D O I：

10.4103/0973-1482.126452

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Aims: The study aimed to assess the diffused expression of p53 protein in patients with OSCC and its association with age at diagnosis (using 50 years as a cut point). Study Design: Ten normal oral mucosa and sixty OSCC lesions from age-distinct patient populations were immunohistochemically analyzed for the expression of p53 protein. Results: In OSCC cases, 31 out of total 60 cases (51.67%) showed positive expression for p53 protein and it was more common in older study group (56.67%) than in younger study group (46.67%) but the difference was not statistically significant. Moreover, there was also no significant difference in the p53 indices (percentage of p53 positive cells) between the two study groups (P = 0.827). Conclusion: The alteration rates were found to be slightly higher in older patients although not statistically significant.

引用

页码：587 / 591

页数：5

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