Structures and Receptor Binding of Hemagglutinins from Human-Infecting H7N9 Influenza Viruses

被引：287

作者：

Shi, Yi ^{[1
,2
]}

Zhang, Wei ^{[2
,3
]}

Wang, Fei ^{[2
,4
]}

Qi, Jianxun ^{[2
]}

Wu, Ying ^{[2
]}

Song, Hao ^{[2
,3
]}

Gao, Feng ^{[5
]}

Bi, Yuhai ^{[2
]}

Zhang, Yanfang ^{[6
]}

Fan, Zheng ^{[7
]}

Qin, Chengfeng ^{[8
]}

Sun, Honglei ^{[4
]}

Liu, Jinhua ^{[4
]}

Haywood, Joel ^{[2
]}

Liu, Wenjun ^{[2
]}

Gong, Weimin ^{[5
]}

Wang, Dayan ^{[9
]}

Shu, Yuelong ^{[9
]}

Wang, Yu ^{[10
]}

Yan, Jinghua ^{[2
]}

Gao, George F. ^{[1
,2
,3
,4
,6
,9
,10
]}

机构：

[1] Chinese Acad Sci, Beijing Inst Life Sci, Res Network Immun & Hlth, Beijing 100101, Peoples R China

[2] Chinese Acad Sci, Inst Microbiol, CAS Key Lab Pathogen Microbiol & Immunol, Beijing 100101, Peoples R China

[3] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

[4] China Agr Univ, Coll Vet Med, Beijing 100193, Peoples R China

[5] Chinese Acad Sci, Inst Biophys, Lab Noncoding RNA, Beijing 100101, Peoples R China

[6] Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Lab Prot Engn & Vaccines, Tianjin 300308, Peoples R China

[7] Chinese Acad Sci, Inst Microbiol, Core Facil, Beijing 100101, Peoples R China

[8] Beijing Inst Microbiol & Epidemiol, Dept Virol, Beijing 100071, Peoples R China

[9] Chinese Ctr Dis Control & Prevent China CDC, Natl Inst Viral Dis Control & Prevent, Beijing 102206, Peoples R China

[10] China CDC, Off Director Gen, Beijing 102206, Peoples R China

来源：

SCIENCE | 2013年 / 342卷 / 6155期

基金：

中国国家自然科学基金;

关键词：

A VIRUS; CONFORMATIONAL-ANALYSIS; TRANSMISSION; ORIGIN; COMPLEXES; OUTBREAK; H1;

D O I：

10.1126/science.1242917

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

An avian-origin human-infecting influenza (H7N9) virus was recently identified in China. We have evaluated the viral hemagglutinin (HA) receptor-binding properties of two human H7N9 isolates, A/Shanghai/1/2013 (SH-H7N9) (containing the avian-signature residue Gln(226)) and A/Anhui/1/2013 (AH-H7N9) (containing the mammalian-signature residue Leu(226)). We found that SH-H7N9 HA preferentially binds the avian receptor analog, whereas AH-H7N9 HA binds both avian and human receptor analogs. Furthermore, an AH-H7N9 mutant HA (Leu(226) -> Gln) was found to exhibit dual receptor-binding property, indicating that other amino acid substitutions contribute to the receptor-binding switch. The structures of SH-H7N9 HA, AH-H7N9 HA, and its mutant in complex with either avian or human receptor analogs show how AH-H7N9 can bind human receptors while still retaining the avian receptor-binding property.

引用

页码：243 / 247

页数：5

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