Immunopathology of multiple sclerosis

被引：1634
作者：
Dendrou, Calliope A. [1 ,2 ]
Fugger, Lars [1 ,2 ,3 ]
Friese, Manuel A. [4 ]
机构：
[1] Univ Oxford, John Radcliffe Hosp, Nuffield Dept Clin Neurosci, Div Clin Neurol, Oxford OX3 9DS, England
[2] Univ Oxford, John Radcliffe Hosp, MRC Human Immunol Unit, Weatherall Inst Mol Med, Oxford OX3 9DS, England
[3] Aarhus Univ Hosp, Inst Clin, DK-8200 Aarhus, Denmark
[4] Univ Klinikum Hamburg Eppendorf, Zentrum Mol Neurobiol Hamburg, Inst Neuroimmunol & Multiple Sklerose, D-20246 Hamburg, Germany
来源：
NATURE REVIEWS IMMUNOLOGY | 2015年 / 15卷 / 09期
基金：
英国医学研究理事会; 英国惠康基金;
关键词：
CD8(+) T-CELLS; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; NERVOUS-SYSTEM AUTOIMMUNITY; HUMAN IMMUNE-SYSTEM; T(H)17 CELLS; MENINGEAL INFLAMMATION; VIRAL-INFECTION; CHOROID-PLEXUS; IFN-GAMMA; B-CELLS;
D O I：
10.1038/nri3871
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Two decades of clinical experience with immunomodulatory treatments for multiple sclerosis point to distinct immunological pathways that drive disease relapses and progression. In light of this, we discuss our current understanding of multiple sclerosis immunopathology, evaluate long-standing hypotheses regarding the role of the immune system in the disease and delineate key questions that are still unanswered. Recent and anticipated advances in the field of immunology, and the increasing recognition of inflammation as an important component of neurodegeneration, are shaping our conceptualization of disease pathophysiology, and we explore the potential implications for improved healthcare provision to patients in the future.
引用
收藏
页码：545 / 558
页数：14
相关论文
共 122 条
[51]  
2-4
[52]   Innate immune activation in neurodegenerative disease [J].
Heneka, Michael T. ;
Kummer, Markus P. ;
Latz, Eicke .
NATURE REVIEWS IMMUNOLOGY, 2014, 14 (07) :463-477
[53]   Meningeal inflammation is widespread and linked to cortical pathology in multiple sclerosis [J].
Howell, Owain W. ;
Reeves, Cheryl A. ;
Nicholas, Richard ;
Carassiti, Daniele ;
Radotra, Bishan ;
Gentleman, Steve M. ;
Serafini, Barbara ;
Aloisi, Francesca ;
Roncaroli, Federico ;
Magliozzi, Roberta ;
Reynolds, Richard .
BRAIN, 2011, 134 :2755-2771
[54]   Analysis of regulatory CD8 T cells in Qa-1-deficient mice [J].
Hu, D ;
Ikizawa, K ;
Lu, LR ;
Sanchirico, ME ;
Shinohara, ML ;
Cantor, H .
NATURE IMMUNOLOGY, 2004, 5 (05) :516-523
[55]   MHC class I restricted myelin epitopes are cross-presented by Tip-DCs that promote determinant spreading to CD8+ T cells [J].
Ji, Qingyong ;
Castelli, Luca ;
Goverman, Joan M. .
NATURE IMMUNOLOGY, 2013, 14 (03) :254-261
[56]   Viral infection triggers central nervous system autoimmunity via activation of CD8+ T cells expressing dual TCRs [J].
Ji, Qingyong ;
Perchellet, Antoine ;
Goverman, Joan M. .
NATURE IMMUNOLOGY, 2010, 11 (07) :628-U99
[57]   Ocrelizumab in relapsing-remitting multiple sclerosis: a phase 2, randomised, placebo-controlled, multicentre trial [J].
Kappos, Ludwig ;
Li, David ;
Calabresi, Peter A. ;
O'Connor, Paul ;
Bar-Or, Amit ;
Barkhof, Frederik ;
Yin, Ming ;
Leppert, David ;
Glanzman, Robert ;
Tinbergen, Jeroen ;
Hauser, Stephen L. .
LANCET, 2011, 378 (9805) :1779-1787
[58]   Cervical cord lesion load is associated with disability independently from atrophy in MS [J].
Kearney, Hugh ;
Altmann, Daniel R. ;
Samson, Rebecca S. ;
Yiannakas, Marios C. ;
Wheeler-Kingshott, Claudia A. M. ;
Ciccarelli, Olga ;
Miller, David H. .
NEUROLOGY, 2015, 84 (04) :367-373
[59]   Preferential Recruitment of Interferon-γ-Expressing TH17 Cells in Multiple Sclerosis [J].
Kebir, Hania ;
Ifergan, Igal ;
Alvarez, Jorge Ivan ;
Bernard, Monique ;
Poirier, Josee ;
Arbour, Nathalie ;
Duquette, Pierre ;
Prat, Alexandre .
ANNALS OF NEUROLOGY, 2009, 66 (03) :390-402
[60]   Neuromyelitis Optica and Asian Phenotype of Multiple Sclerosis [J].
Kira, Jun-ichi .
YEAR IN NEUROLOGY 2008, 2008, 1142 :58-71
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