Immunopathology of multiple sclerosis

被引：1634

作者：

Dendrou, Calliope A. ^{[1
,2
]}

Fugger, Lars ^{[1
,2
,3
]}

Friese, Manuel A. ^{[4
]}

机构：

[1] Univ Oxford, John Radcliffe Hosp, Nuffield Dept Clin Neurosci, Div Clin Neurol, Oxford OX3 9DS, England

[2] Univ Oxford, John Radcliffe Hosp, MRC Human Immunol Unit, Weatherall Inst Mol Med, Oxford OX3 9DS, England

[3] Aarhus Univ Hosp, Inst Clin, DK-8200 Aarhus, Denmark

[4] Univ Klinikum Hamburg Eppendorf, Zentrum Mol Neurobiol Hamburg, Inst Neuroimmunol & Multiple Sklerose, D-20246 Hamburg, Germany

来源：

NATURE REVIEWS IMMUNOLOGY | 2015年 / 15卷 / 09期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

CD8(+) T-CELLS; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; NERVOUS-SYSTEM AUTOIMMUNITY; HUMAN IMMUNE-SYSTEM; T(H)17 CELLS; MENINGEAL INFLAMMATION; VIRAL-INFECTION; CHOROID-PLEXUS; IFN-GAMMA; B-CELLS;

D O I：

10.1038/nri3871

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Two decades of clinical experience with immunomodulatory treatments for multiple sclerosis point to distinct immunological pathways that drive disease relapses and progression. In light of this, we discuss our current understanding of multiple sclerosis immunopathology, evaluate long-standing hypotheses regarding the role of the immune system in the disease and delineate key questions that are still unanswered. Recent and anticipated advances in the field of immunology, and the increasing recognition of inflammation as an important component of neurodegeneration, are shaping our conceptualization of disease pathophysiology, and we explore the potential implications for improved healthcare provision to patients in the future.

引用

页码：545 / 558

页数：14

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