Wnt/β-catenin signaling regulates neuronal differentiation of mesenchymal stem cells

被引：31
作者：
Yu, Qin [1 ]
Liu, Lizhen [2 ]
Duan, Yanping [1 ]
Wang, Yan [3 ]
Xuan, Xiaobo [3 ]
Zhou, Liping [1 ]
Liu, Wei [1 ]
机构：
[1] Zhejiang Chinese Med Univ, Inst Bioengn, Hangzhou 310053, Zhejiang, Peoples R China
[2] Zhejiang Univ, Sch Med, Affiliated Hosp 1, Bone Marrow Transplantat Ctr, Hangzhou 310003, Zhejiang, Peoples R China
[3] Zhejiang Chinese Med Univ, Affiliated Hosp 1, Hangzhou 310053, Zhejiang, Peoples R China
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2013年 / 439卷 / 02期
关键词：
Mesenchymal stem cells; Wnt/beta-catenin signaling; Neuronal differentiation; Wnt-3a; MARROW STROMAL CELLS; BONE-MARROW; MECHANISMS; WNT-3A; TRANSPLANTATION; PROGENITORS; EXPRESSION; INDUCTION; INJURY; MICE;
D O I：
10.1016/j.bbrc.2013.08.030
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Mesenchymal stem cells (MSCs) have been demonstrated to be able to differentiate into neuron-like cells, but the precise mechanisms controlling this process are unclear. Using neuron-specific enolase (NSE) and nestin as neuronal markers, we examined the role of Wnt/beta-catenin signaling in MSC neuronal differentiation in present study. The results indicated that the expression of beta-catenin increased markedly during the neuronal differentiation of MSCs. Blocking Wnt signaling by treating MSCs with beta-catenin siRNA could decrease the differentiation of MSCs into neuron-like cells and up-regulation of Wnt signaling by treating MSCs with Wnt-3a could promote neuronal differentiation of MSCs. Above results suggest that Wnt/beta-catenin signaling may play a pivotal role in neuronal differentiation of MSCs. Our data broaden the knowledge of molecular mechanisms involved in the neuronal differentiation of MSCs and provide a potential target for directing differentiation of MSCs for clinical application. (C) 2013 Elsevier Inc. All rights reserved.
引用
收藏
页码：297 / 302
页数：6
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