1,2,3-Triazole derivatives of 3-ferrocenylidene-2-oxindole: Synthesis, characterization, electrochemical and antimicrobial evaluation

被引：18

作者：

Yagnam, Swetha ^{[1
,5
]}

Reddy, Eda Rami ^{[1
]}

Trivedi, Rajiv ^{[1
,5
]}

Krishna, Narra Vamshi ^{[2
]}

Giribabu, Lingamallu ^{[2
,5
]}

Rathod, Balaji ^{[3
]}

Prakasham, Reddy Shetty ^{[3
,5
]}

Sridhar, Balasubramanian ^{[4
,5
]}

机构：

[1] Indian Inst Chem Technol, CSIR, Catalysis & Fine Chem Div, Uppal Rd, Hyderabad 500007, Telangana, India

[2] Indian Inst Chem Technol, CSIR, Polymer & Funct Mat Div, Hyderabad 500007, Telangana, India

[3] Indian Inst Chem Technol, CSIR, Organ Synth & Proc Chem, Hyderabad 500007, Telangana, India

[4] Indian Inst Chem Technol, CSIR, Ctr Xray Crystallog, Hyderabad 500007, Telangana, India

[5] CSIR, AcSIR, Acad Sci & Innovat Res, IICT Campus, Hyderabad 500007, Telangana, India

来源：

APPLIED ORGANOMETALLIC CHEMISTRY | 2019年 / 33卷 / 04期

关键词：

antimicrobial activity; aryl; benzyl; electrochemistry; ferrocene-conjugated oxindole; sugar and aliphatic azides; triazoles; CLICK CHEMISTRY; ANTIMALARIAL ACTIVITY; BIOLOGICAL-ACTIVITY; IN-VITRO; FERROCENE; CANCER; CHLOROQUINE; FERROQUINE; TRIAZOLES; SERIES;

D O I：

10.1002/aoc.4817

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A series of bioactive, triazole-linked benzyl, aryl, sugar and aliphatic conjugates of 3-ferrocenylidene-oxindole have been synthesized. A facile 1,3-dipolar-Huisgen coupling reaction of the respective azides with the 3-ferrocenylidene-oxindole N-propargyl moiety (3) gave the corresponding conjugates (5a-n). All the newly synthesized compounds (5a-n) were characterized by H-1-NMR, C-13-NMR, HRMS, Fourier transform-infrared spectroscopy and elemental analysis. The UV-Vis and electrochemical studies of these compounds were performed in dimethylsulfoxide solutions. The structure of compound (3) was determined by single crystal X-ray diffraction study. These compounds exhibited moderate to good antimicrobial activity against Gram-positive and Gram-negative strains.

引用

页数：15

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