1,2,3-Triazole derivatives of 3-ferrocenylidene-2-oxindole: Synthesis, characterization, electrochemical and antimicrobial evaluation

A series of bioactive, triazole-linked benzyl, aryl, sugar and aliphatic conjugates of 3-ferrocenylidene-oxindole have been synthesized. A facile 1,3-dipolar-Huisgen coupling reaction of the respective azides with the 3-ferrocenylidene-oxindole N-propargyl moiety (3) gave the corresponding conjugates (5a-n). All the newly synthesized compounds (5a-n) were characterized by H-1-NMR, C-13-NMR, HRMS, Fourier transform-infrared spectroscopy and elemental analysis. The UV-Vis and electrochemical studies of these compounds were performed in dimethylsulfoxide solutions. The structure of compound (3) was determined by single crystal X-ray diffraction study. These compounds exhibited moderate to good antimicrobial activity against Gram-positive and Gram-negative strains.