Reduction of osteonecrosis of the jaw (ONJ) after implementation of preventive measures in patients with multiple myeloma treated with zoledronic acid

被引：295

作者：

Dimopoulos, M. A. ^{[1
]}

Kastritis, E. ^{[1
]}

Bamia, C. ^{[2
]}

Melakopoulos, I.

Gika, D. ^{[1
]}

Roussou, M. ^{[1
]}

Migkou, M. ^{[1
]}

Eleftherakis-Papaiakovou, E. ^{[1
]}

Christoulas, D. ^{[1
]}

Terpos, E. ^{[3
]}

Bamias, A. ^{[1
]}

机构：

[1] Univ Athens, Sch Med, Dept Clin Therapeut, GR-11527 Athens, Greece

[2] Univ Athens, Sch Med, Dept Hyg & Epidemiol, GR-11527 Athens, Greece

[3] 251 Gen Air Force Hosp, Dept Biomed Res, Athens, Greece

来源：

ANNALS OF ONCOLOGY | 2009年 / 20卷 / 01期

关键词：

RISK-FACTORS; BISPHOSPHONATES; PAMIDRONATE; NECROSIS; CANCER;

D O I：

10.1093/annonc/mdn554

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Osteonecrosis of the jaw (ONJ) is a well-described complication of bisphosphonates use in patients with multiple myeloma (MM). We investigated whether the occurrence of ONJ decreased after the implementation of preventive measures in 128 patients with MM who received zoledronic acid. Patients and methods: Patients with MM who received zoledronic acid were included in this analysis. Patients with a previous use of other bisphosphonates were excluded; patients were stratified into group A (n = 38) and group B (n = 90) if treatment was started before or after the implementation of preventive measures. Results: One hundred and twenty-eight patients were included in this analysis. Sixteen patients (12.5%) developed ONJ-025EFgroup A: 8 (26.3%), group B: 2 (6.7%) (P = 0.002). The incidence rate (IR) was 0.671/100 person-months for group A and 0.230/100 person-months for group B [IR ratio 2.92, P = 0.029, 95% confidence interval 1.06-8.03]. No patient in group B developed stage III ONJ. Conclusion: In conclusion, the risk of developing ONJ after treatment of zoledronic acid is reduced (but not deleted) by the implementation of preventive measures.

引用

页码：117 / 120

页数：4

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