Newly identified synergy between clopidogrel and calcium-channel blockers for blood pressure regulation possibly involves CYP2C19 rs4244285

被引：3
作者：
Stathopoulou, Maria G. [1 ]
Monteiro, Pedro [2 ,3 ]
Shahabi, Payman [1 ]
Penas-Lledo, Eva [4 ]
El Shamieh, Said [1 ]
Santos, Luis Silva [5 ]
Thilly, Nathalie [6 ]
Siest, Gerard [1 ]
Llerena, Adrian [4 ]
Visvikis-Siest, Sophie [1 ,7 ]
机构：
[1] Univ Lorraine, UMR INSERM U1122, IGE PCV Interact Gene Environm Physiopathol Cardi, F-54000 Nancy, France
[2] Univ Coimbra, Fac Med, P-3004504 Coimbra, Portugal
[3] Univ Hosp Coimbra, EPE, P-3000075 Coimbra, Portugal
[4] Extremadura Univ Hosp & Med Sch, CICAB Clin Res Ctr, Badajoz 06080, Spain
[5] Portuguese Catholic Univ, Hlth Sci Inst, P-3504505 Viseu, Portugal
[6] Univ Hosp Nancy, Dept Clin Epidemiol & Evaluat, F-54500 Vandoeuvre Les Nancy, France
[7] CHU Nancy Brabois, Dept Internal Med & Geriatr, F-54500 Vandoeuvre Les Nancy, France
来源：
INTERNATIONAL JOURNAL OF CARDIOLOGY | 2013年 / 168卷 / 03期
关键词：
Clopidogrel; Calcium-channel blockers; Blood pressure; Synergy; CYP2C19; polymorphism; EFFICACY;
D O I：
10.1016/j.ijcard.2013.04.097
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
[No abstract available]
引用
收藏
页码：3057 / 3058
页数：3
相关论文
共 10 条
[1]   Extraadrenal 21-Hydroxylation by CYP2C19 and CYP3A4: Effect on 21-Hydroxylase Deficiency [J].
Gomes, Larissa G. ;
Huang, Ningwu ;
Agrawal, Vishal ;
Mendonca, Berenice B. ;
Bachega, Tania A. S. S. ;
Miller, Walter L. .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2009, 94 (01) :89-95
[2]   Is There a Clinically Significant Interaction Between Calcium Channel Antagonists and Clopidogrel? Results From the Clopidogrel for the Reduction of Events During Observation (CREDO) Trial [J].
Good, Christopher W. ;
Steinhubl, Steven R. ;
Brennan, Danielle M. ;
Lincoff, A. Michael ;
Topol, Eric J. ;
Berger, Peter B. .
CIRCULATION-CARDIOVASCULAR INTERVENTIONS, 2012, 5 (01) :77-81
[3]   Calcium-channel blockers decrease clopidogrel-mediated platelet inhibition [J].
Gremmel, Thomas ;
Steiner, Sabine ;
Seidinger, Daniela ;
Koppensteiner, Renate ;
Panzer, Simon ;
Kopp, Christoph W. .
HEART, 2010, 96 (03) :186-189
[4]   Clopidogrel improves systemic endothelial nitric oxide bioavailability in patients with coronary artery disease -: Evidence for antioxidant and antiinflammatory effects [J].
Heitzer, Thomas ;
Rudolph, Volker ;
Schwedhelm, Edzard ;
Karstens, Manuela ;
Sydow, Karsten ;
Ortak, Michelle ;
Tschentscher, Peter ;
Meinertz, Thomas ;
Boeger, Rainer ;
Baldus, Stephan .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2006, 26 (07) :1648-1652
[5]   Inhibitory Interaction Between Calcium Channel Blocker and Clopidogrel - Efficacy of Cilostazol to Overcome It [J].
Lee, Seung-Pyo ;
Bae, Jang-Whan ;
Park, Kyung Woo ;
Rha, Seung-Woon ;
Bae, Jang-Ho ;
Suh, Jung-Won ;
Chae, In-Ho ;
Cho, Myeong-Chan ;
Kim, Hyo-Soo .
CIRCULATION JOURNAL, 2011, 75 (11) :2581-2589
[6]   Antiplatelet drug interactions [J].
Mackenzie, I. S. ;
Coughtrie, M. W. H. ;
MacDonald, T. M. ;
Wei, L. .
JOURNAL OF INTERNAL MEDICINE, 2010, 268 (06) :516-529
[7]   Calcium-Channel Blockers Do Not Alter the Clinical Efficacy of Clopidogrel After Myocardial Infarction A Nationwide Cohort Study [J].
Olesen, Jonas B. ;
Gislason, Gunnar H. ;
Charlot, Mette G. ;
Fosbol, Emil L. ;
Andersson, Charlotte ;
Weeke, Peter ;
Ahlehoff, Ole ;
Selmer, Christian ;
Torp-Pedersen, Christian ;
Hansen, Peter R. .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2011, 57 (04) :409-417
[8]   Apolipoprotein E serum concentration and polymorphism in six European countries: the ApoEurope Project [J].
Schiele, F ;
De Bacquer, D ;
Vincent-Viry, M ;
Beisiegel, U ;
Ehnholm, C ;
Evans, A ;
Kafatos, A ;
Martins, MC ;
Sans, S ;
Sass, C ;
Visvikis, S ;
De Backer, G ;
Siest, G .
ATHEROSCLEROSIS, 2000, 152 (02) :475-488
[9]   Calcium-Channel Blockers Reduce the Antiplatelet Effect of Clopidogrel [J].
Siller-Matula, Jolanta M. ;
Lang, Irene ;
Christ, Guenter ;
Jilma, Bernd .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2008, 52 (19) :1557-1563
[10]   ADP receptor P2Y12 is expressed in vascular smooth muscle cells and stimulates contraction in human blood vessels [J].
Wihlborg, AK ;
Wang, LW ;
Braun, OÖ ;
Eyjolfsson, A ;
Gustafsson, R ;
Gudbjartsson, T ;
Erlinge, D .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2004, 24 (10) :1810-1815
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