Incorporation of Poly[(R)-3-hydroxybutyrate] into Cationic Copolymers Based on Poly(2-(dimethylamino)ethyl methacrylate) to Improve Gene Delivery

被引：48
作者：
Loh, Xian Jun [1 ]
Ong, Shi Jie [2 ]
Tung, Yin Ting [2 ]
Choo, Hoi Teng [2 ]
机构：
[1] ASTAR, Inst Mat Res & Engn, Singapore 117602, Singapore
[2] Singapore Polytech, Sch Chem & Life Sci, Singapore 139651, Singapore
来源：
MACROMOLECULAR BIOSCIENCE | 2013年 / 13卷 / 08期
关键词：
biodegradable polymer; gene delivery formulation; poly(2-(dimethylamino)ethyl methacrylate); poly[(R)-3-hydroxybutyrate; transfection efficiency; TRANSFER RADICAL POLYMERIZATION; BETA-CYCLODEXTRIN CORES; MURINE XENOGRAFT MODEL; IN-VITRO; TRANSFECTION EFFICIENCY; TRIBLOCK COPOLYMERS; BLOCK-COPOLYMERS; SIRNA DELIVERY; NANOPARTICLES; MICELLES;
D O I：
10.1002/mabi.201300050
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The synthesis and gene transfection efficiency of a series of novel amphiphilic triblock copolymers with two hydrophilic poly(2-(dimethylamino)ethyl methacrylate) (DMAEMA) blocks flanking a central hydrophobic poly[(R)-3-hydroxybutyrate] (PHB) block is reported. These copolymers have significantly lower toxicity compared to the polyethyleneimine (PEI) and PDMAEMA homopolymer. Unexpectedly, the incorporation of PHB significantly improves the gene transfection efficiency as compared to PEI or PDMAEMA homopolymers.
引用
收藏
页码：1092 / 1099
页数：8
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