Therapeutic targeting of EPH receptors and their ligands

被引：281

作者：

Boyd, Andrew W. ^{[1
]}

Bartlett, Perry F. ^{[2
]}

Lackmann, Martin ^{[3
]}

机构：

[1] Queensland Inst Med Res, Leukaemia Fdn Res Lab, Brisbane, Qld 4029, Australia

[2] Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia

[3] Monash Univ, Dept Biochem & Mol Biol, Clayton, Vic 3800, Australia

来源：

NATURE REVIEWS DRUG DISCOVERY | 2014年 / 13卷 / 01期

基金：

英国科研创新办公室;

关键词：

TYROSINE KINASE EPHB4; SPINAL-CORD-INJURY; GROWTH-FACTOR RECEPTOR; CELL-LUNG-CANCER; UP-REGULATION; PROSTATE-CANCER; AXONAL REGENERATION; TUMOR-SUPPRESSOR; BREAST-CANCER; STEM-CELLS;

D O I：

10.1038/nrd4175

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Critical roles for EPH receptor (EPH)-ephrin signalling in a range of chronic and regenerative diseases are increasingly being recognized. In particular, the complex roles of EPHs and ephrins in tumour growth and progression, and in nerve injury and regeneration have been studied extensively. This has led to considerable progress in developing strategies for their therapeutic targeting, with some anticancer agents already in clinical trials. Promising leads for non-malignant diseases are also emerging, with compelling preclinical data encouraging clinical development. We discuss this rapidly developing area of drug discovery, highlighting the associated challenges and limitations.

引用

页码：39 / 62

页数：24

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