Phenotypic plasticity and epithelial-to-mesenchymal transition in the behaviour and therapeutic response of oral squamous cell carcinoma

被引：21

作者：

Vig, Navin ^{[1
]}

Mackenzie, Ian C. ^{[1
]}

Biddle, Adrian ^{[1
]}

机构：

[1] Queen Mary Univ London, Blizard Inst, Barts & London Sch Med & Dent, London, England

来源：

JOURNAL OF ORAL PATHOLOGY & MEDICINE | 2015年 / 44卷 / 09期

基金：

英国国家替代、减少和改良动物研究中心;

关键词：

cancer; epithelial-to-mesenchymal transition; heterogeneity; mesenchymal-to-epithelial transition; plasticity; CANCER STEM-CELLS; TGF-BETA; E-CADHERIN; HEAD; METASTASIS; EXPRESSION; EMT; MECHANISMS; ZEB1; ASSOCIATION;

D O I：

10.1111/jop.12306

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

It is increasingly recognised that phenotypic plasticity, apparently driven by epigenetic mechanisms, plays a key role in tumour behaviour and markedly influences the important processes of therapeutic survival and metastasis. An important source of plasticity in malignancy is epithelial-to-mesenchymal transition (EMT), a common epigenetically controlled event that results in transition of malignant cells between different phenotypic states that confer motility and enhance survival. In this review, we discuss the importance of phenotypic plasticity and its contribution to cellular heterogeneity in oral squamous cell carcinoma with emphasis on aspects of drug resistance and EMT.

引用

页码：649 / 655

页数：7

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